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通过全面的文献计量分析揭示癌症相关miRNA机制的新兴研究热点，为精准医学和非侵入性诊断提供参考。

Unveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and non-invasive diagnostics.

作者信息

Zhang Zhirui, Song Wenhuan, Chen Wenyu, Cui Wenze, Chen Wenyi, Zhang Qinheng, Ji Wenwen, Wang Yinglin, Wang Jiayi, Yu Wenhao, Yu Mingkun, Hao Tao, Jiang Hong

机构信息

Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, Shandong, China.

College of Traditional Chinese Medicine, Binzhou Medical University, Yantai, Shandong, China.

出版信息

Front Oncol. 2025 Jan 15;14:1521251. doi: 10.3389/fonc.2024.1521251. eCollection 2024.

DOI:10.3389/fonc.2024.1521251
PMID:39882450
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11774920/
Abstract

BACKGROUND AND OBJECTIVE: MicroRNAs (miRNAs) are implicated in cancer by exerting roles in tumor growth, metastasis, and even drug resistance. The general trends of miRNA research in diverse cancers are not fully understood. In this work, miRNA-related research in colorectal cancer, prostate cancer, leukemia, and brain tumors was analyzed in search of key research trends with clinical potential. METHODS: A bibliometric analysis of articles, spanning from 2014 to 2024, was carried out with the major focus laid on four types of cancers. The Co-citation network analysis, keyword bursts, and the collaborative pattern were done in VOSviewer and CiteSpace, respectively. RESULTS: Colorectal cancer had the highest publication volume, with research primarily focusing on gene expression, extracellular vesicles, and non-coding RNAs. Prostate cancer showed a shift toward clinical applications, while leukemia and brain tumor research, though less extensive, highlighted miRNA's potential in early diagnosis and treatment. Co-citation analysis identified emerging research collaborations and key contributors. CONCLUSION: miRNA plays a pivotal role in cancer diagnosis, biomarker development, and therapeutic interventions. With advancements in non-invasive diagnostics and personalized medicine, miRNA offers significant potential for clinical applications. Future research should focus on miRNA's role in drug resistance and combination therapies to accelerate its clinical translation.

摘要

背景与目的：微小RNA（miRNA）通过在肿瘤生长、转移甚至耐药性方面发挥作用而与癌症相关。目前对miRNA在多种癌症中的研究总体趋势尚未完全了解。在本研究中，对结直肠癌、前列腺癌、白血病和脑肿瘤中与miRNA相关的研究进行了分析，以寻找具有临床潜力的关键研究趋势。 方法：对2014年至2024年期间的文章进行文献计量分析，主要聚焦于四种癌症类型。共被引网络分析、关键词突现分析和合作模式分析分别在VOSviewer和CiteSpace中进行。 结果：结直肠癌的发表量最高，研究主要集中在基因表达、细胞外囊泡和非编码RNA方面。前列腺癌的研究向临床应用方向转变，而白血病和脑肿瘤的研究虽然规模较小，但突出了miRNA在早期诊断和治疗中的潜力。共被引分析确定了新兴的研究合作和关键贡献者。 结论：miRNA在癌症诊断、生物标志物开发和治疗干预中起关键作用。随着非侵入性诊断和个性化医学的进展，miRNA在临床应用中具有巨大潜力。未来的研究应聚焦于miRNA在耐药性和联合治疗中的作用，以加速其临床转化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/a9df9d704e44/fonc-14-1521251-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/428b75f4c209/fonc-14-1521251-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/2072d37fda9f/fonc-14-1521251-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/016942048376/fonc-14-1521251-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/503f808e5623/fonc-14-1521251-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/b12af7439e27/fonc-14-1521251-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/708f99e4ec09/fonc-14-1521251-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/f9b316a83dd8/fonc-14-1521251-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/a9df9d704e44/fonc-14-1521251-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/428b75f4c209/fonc-14-1521251-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/2072d37fda9f/fonc-14-1521251-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/016942048376/fonc-14-1521251-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/503f808e5623/fonc-14-1521251-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/b12af7439e27/fonc-14-1521251-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/708f99e4ec09/fonc-14-1521251-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/f9b316a83dd8/fonc-14-1521251-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ced3/11774920/a9df9d704e44/fonc-14-1521251-g008.jpg

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引用本文的文献

[1]
Huashi Jiedu Decoction Enhances 5-Fluorouracil Efficacy in Gastric Cancer via miRNA-21-3p/p53 Pathway.

Drug Des Devel Ther. 2025-5-15

本文引用的文献

[1]
miR-21 and miR-145 as Prognostic Biomarkers for Radiotherapy Responses in Cervical Cancer Patients: A Preliminary Study.

Int J Mol Sci. 2024-9-30

[2]
Targeted gene therapy for cancer: the impact of microRNA multipotentiality.

Med Oncol. 2024-8-1

[3]
MicroRNA-34 Family in Cancers: Role, Mechanism, and Therapeutic Potential.

Cancers (Basel). 2023-9-26

[4]
MiRNAs in Hematopoiesis and Acute Lymphoblastic Leukemia.

Int J Mol Sci. 2023-3-12

[5]
A nomogram model based on the number of examined lymph nodes-related signature to predict prognosis and guide clinical therapy in gastric cancer.

Front Immunol. 2022

[6]
Identification of MicroRNAs as Viable Aggressiveness Biomarkers for Prostate Cancer.

Biomedicines. 2021-6-5

[7]
MicroRNAs as important contributors in the pathogenesis of colorectal cancer.

Biomed Pharmacother. 2021-8

[8]
MicroRNA‑137 regulates hypoxia‑mediated migration and epithelial‑mesenchymal transition in prostate cancer by targeting LGR4 via the EGFR/ERK signaling pathway.

Int J Oncol. 2020-8

[9]
miR-155 as a novel clinical target for hematological malignancies.

Carcinogenesis. 2020-3-13

[10]
Circulating miR-1290 and miR-320d as Novel Diagnostic Biomarkers of Human Colorectal Cancer.

J Cancer. 2019-1-1

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