Wei Loo Keat, Fu Chun Chong, Menon Saras, Griffiths Lyn R
Centre for Biomedical and Nutrition Research (CBNR), Universiti Tunku Abdul Rahman, Bandar Barat, 31900 Kampar, Perak, Malaysia; Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, 31900 Kampar, Perak, Malaysia.
Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Bandar Barat, 31900 Kampar, Perak, Malaysia.
Gene. 2025 Aug 15;961:149533. doi: 10.1016/j.gene.2025.149533. Epub 2025 Apr 25.
MicroRNAs (miRNAs) are critical regulators of stroke pathophysiology, influencing neuroinflammation, neuronal survival, and post-stroke recovery. This study presents a comprehensive bibliometric analysis of 1,988 miRNA-stroke research articles published over the past 42 years, mapping the intellectual landscape, emerging research hotspots, and future directions within the field. Using Python, VOSviewer, and CiteSpace, we identified influential studies, leading authors, collaborative networks, and key thematic clusters that are advancing research. Our analysis highlights several emerging hotspots, including exosomal miRNA biomarkers for stroke diagnosis, miRNA-based therapeutics, and regulatory networks involving circRNAs and lncRNAs, which present promising avenues for precision medicine. Citation burst and timeline analyses highlight the growing focus on miRNA-targeted interventions, epigenetic modifications, and neuroprotective strategies, which are rapidly shaping the evolution of stroke research. Importantly, we emphasize the need for increased research in human-based studies to validate these findings and ensure clinical applicability. This study provides a structured framework to guide future research efforts, promoting international collaboration and bridging the gap between fundamental discoveries and the clinical translation of miRNA-based diagnostics and therapeutics in stroke.
微小RNA（miRNA）是中风病理生理学的关键调节因子，影响神经炎症、神经元存活和中风后恢复。本研究对过去42年发表的1988篇miRNA-中风研究文章进行了全面的文献计量分析，描绘了该领域的知识版图、新兴研究热点和未来方向。我们使用Python、VOSviewer和CiteSpace，确定了推动该研究的有影响力的研究、主要作者、合作网络和关键主题集群。我们的分析突出了几个新兴热点，包括用于中风诊断的外泌体miRNA生物标志物、基于miRNA的治疗方法以及涉及环状RNA（circRNA）和长链非编码RNA（lncRNA）的调控网络，这些为精准医学提供了有前景的途径。引用爆发和时间线分析突出了对miRNA靶向干预、表观遗传修饰和神经保护策略日益增加的关注，这些正在迅速塑造中风研究的发展。重要的是，我们强调需要增加基于人类的研究，以验证这些发现并确保临床适用性。本研究提供了一个结构化框架，以指导未来的研究工作，促进国际合作，并弥合中风中基于miRNA的诊断和治疗的基础发现与临床转化之间的差距。
