Biddle Gregory J H, Henson Joseph, Davies Melanie J, Dunstan David, Khunti Kamlesh, King James A, Rowlands Alex V, Edwardson Charlotte L, Yates Thomas
Diabetes Research Centre, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Leicester, UK.
J Sports Sci. 2025 Feb;43(3):223-233. doi: 10.1080/02640414.2024.2447660. Epub 2025 Jan 30.
Acute studies have consistently demonstrated small-to-medium glycaemic responses to breaking prolonged sitting, yet it is not known whether acute effects are maintained following a period of intervention or whether behavioural interventions lead to sustained benefits. A single arm, 4-week intervention with pre and post "two-arm" randomised cross-over conditions, study was conducted to investigate whether reducing prolonged sitting in free-living affects acute and chronic glucose and insulin responses. Adults aged 40-75 years living with overweight or obesity with an elevated HbA1c (5.7-7.5%) underwent four experimental conditions (two prolonged sitting [CON], two sitting with a self-paced light upright movement breaks [LUMB]) in a randomised order. One of each condition was conducted before and after the intervention. A total of 33 participants completed the study. There was no change in sitting or glucose/insulin levels over the 4-week intervention. However, glucose and insulin were reduced acutely in the LUMB conditions compared with CON (glucose [mmol/L]: CON: 5.77 [5.51; 6.02], LUMB: 5.55 [5.30; 5.81], = 0.006, insulin [mIU/L]: (CON: 77.70 [61.58; 93.83], LUMB: 61.28 [51.19; 71.38], = <0.001); these responses did not change over time. In conclusion, the intervention did not lead to reduced sitting time or chronic changes to postprandial metabolism.
急性研究一直表明，打破长时间久坐会产生小到中等程度的血糖反应，但尚不清楚在一段时间的干预后急性效应是否会持续，也不清楚行为干预是否会带来持续的益处。本研究采用单组、为期4周的干预，并设置了干预前后的“双臂”随机交叉条件，以调查在自由生活中减少久坐是否会影响急性和慢性葡萄糖及胰岛素反应。40 - 75岁、超重或肥胖且糖化血红蛋白升高（5.7 - 7.5%）的成年人按随机顺序接受了四种实验条件（两种长时间久坐[CON]，两种在有自定节奏的轻度直立运动间歇的情况下久坐[LUMB]）。每种条件中的一种在干预前后各进行一次。共有33名参与者完成了研究。在为期4周的干预期间，久坐时间或葡萄糖/胰岛素水平没有变化。然而，与CON相比，LUMB条件下的葡萄糖和胰岛素在急性时有所降低（葡萄糖[mmol/L]：CON：5.77[5.51；6.02]，LUMB：5.55[5.30；5.81]，P = 0.006，胰岛素[mIU/L]：（CON：77.70[61.58；93.83]，LUMB：61.28[51.19；71.38]，P = <0.001）；这些反应并未随时间变化。总之，该干预并未导致久坐时间减少或餐后代谢的慢性变化。
