School of Health and Exercise Sciences, University of British Columbia, Okanagan Campus, Kelowna, British Columbia, CANADA.
College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, CANADA.
Med Sci Sports Exerc. 2021 Jan;53(1):150-158. doi: 10.1249/MSS.0000000000002431.
Prolonged sitting is associated with cardiometabolic complications. The study purpose was to investigate whether breaking up prolonged sitting with brief stair climbing exercise "snacks" could lower postprandial insulin, glucose, and free fatty acids responses.
In two separate randomized crossover studies, 12 young healthy-weight men (study 1) and 11 adults with overweight/obesity (OW; study 2) completed two experimental conditions: i) sedentary (SED; 9-h sitting) and ii) stair climbing snacks (SS; 8 × 15-30 s once per hour). The same high-glycemic index meals were consumed at 0, 3, and 6 h at each condition. The primary outcome was total insulin area under the curve (AUC) across 9 h.
In healthy-weight men, there were no significant differences between SS and SED for total (9-h) insulin AUC (P = 0.24, d = 0.4), total glucose AUC (P = 0.17, d = 0.48), total nonesterified fatty acid (NEFA) AUC (P = 0.22, d = 0.4), or total triglyceride AUC (P = 0.72). In adults with OW, total insulin AUC (-16.5%, P = 0.036, d = 0.94) and total NEFA AUC (-21%, P = 0.016, d = 1.2) were significantly lower in SS versus SED. No differences were found for total glucose and triglyceride AUC (all, P > 0.31) in participants with OW.
Breaking up 9 h of prolonged sitting with hourly brief stair climbing exercise snacks lowered postprandial insulin and NEFA levels in adults with overweight/obesity.
长时间坐着与心血管代谢并发症有关。本研究旨在探讨短暂的爬楼梯运动“零食”是否可以打断长时间久坐，从而降低餐后胰岛素、葡萄糖和游离脂肪酸的反应。
在两项独立的随机交叉研究中，12 名年轻健康体重的男性（研究 1）和 11 名超重/肥胖的成年人（OW；研究 2）分别完成了两种实验条件：i）久坐（SED；9 小时坐姿）和 ii）爬楼梯零食（SS；每小时 1 次，每次 15-30 秒）。在每个条件下，在 0、3 和 6 小时进食相同的高血糖指数餐。主要结果是 9 小时内总胰岛素曲线下面积（AUC）。
在健康体重的男性中，SS 和 SED 之间的总（9 小时）胰岛素 AUC 无显著差异（P = 0.24，d = 0.4），总葡萄糖 AUC（P = 0.17，d = 0.48），总非酯化脂肪酸（NEFA）AUC（P = 0.22，d = 0.4）或总甘油三酯 AUC（P = 0.72）。在 OW 成年人中，SS 与 SED 相比，总胰岛素 AUC（-16.5%，P = 0.036，d = 0.94）和总 NEFA AUC（-21%，P = 0.016，d = 1.2）明显降低。OW 参与者的总葡萄糖和甘油三酯 AUC 没有差异（均，P > 0.31）。
用每小时短暂的爬楼梯运动零食打断 9 小时的久坐时间，可降低超重/肥胖成年人的餐后胰岛素和 NEFA 水平。
