Christodoulou Ioanna, Gkaniatsou Effrosyni, Steunou Nathalie, Kisserli Aymric, Cohen Jacques H M, Haouas Mohamed, Sicard Clémence
Institut Lavoisier de Versailles, UMR CNRS 8180, UVSQ, Université Paris-Saclay, 78035 Versailles, France.
Nanosciences Research Laboratory LRN EA 4682, University of Rheims Champagne-Ardenne, 51685 Rheims, France.
Inorg Chem. 2025 Feb 10;64(5):2545-2553. doi: 10.1021/acs.inorgchem.4c05275. Epub 2025 Jan 30.
An effective approach for the immobilization and protection of biological entities is their encapsulation via the in situ synthesis of metal-organic frameworks (MOFs). To ensure the preservation of the bioentities, mild synthetic conditions, including aqueous media and ambient conditions (temperature and pressure), are preferred. In this study, we investigated the synthesis of various aluminum polycarboxylate-based MOFs, including the fumarate, terephthalate, amino-terephthalate, and muconate forms of MIL-53(Al), as well as the MIL-110 and MIL-160 MOF types. The potential as immobilization matrices was then assessed using bovine serum albumin (BSA). Finally, was selected for the encapsulation of a mixture of polysaccharides and more structurally complex bioentities (viruses).
一种用于固定和保护生物实体的有效方法是通过金属有机框架（MOF）的原位合成对其进行封装。为确保生物实体的保存，优选温和的合成条件，包括水性介质和环境条件（温度和压力）。在本研究中，我们研究了各种基于铝多羧酸盐的MOF的合成，包括MIL-53(Al)的富马酸盐、对苯二甲酸盐、氨基对苯二甲酸盐和粘康酸盐形式，以及MIL-110和MIL-160 MOF类型。然后使用牛血清白蛋白（BSA）评估其作为固定基质的潜力。最后，选择用于封装多糖混合物和结构更复杂的生物实体（病毒）。
