Blain P G, Lane R J, Bateman D N, Rawlins M D
Hum Toxicol. 1985 Jan;4(1):71-4. doi: 10.1177/096032718500400109.
Three patients with opiate self-poisoning developed acute muscle damage with elevated serum aspartate aminotransferase and creatine kinase activities, increased serum myoglobin concentrations, raised plasma creatinine concentrations, hypocalcaemia and hyperphosphataemia. These abnormalities gradually resolved over 7-10 days, but recovery was complicated due to the development of acute renal failure (requiring haemodialysis) in one patient. Plasma drug concentrations, shortly after admission, in the patients taking dihydrocodeine and morphine were grossly elevated (184 and 60 micrograms/l respectively). Clinical evidence of myopathy was minimal in all three patients and muscle biopsy of one patient was normal at 7 days.
三名阿片类药物中毒患者出现急性肌肉损伤，血清天冬氨酸转氨酶和肌酸激酶活性升高，血清肌红蛋白浓度增加，血浆肌酐浓度升高，低钙血症和高磷血症。这些异常在7 - 10天内逐渐消退，但一名患者因发生急性肾衰竭（需要血液透析）而使恢复过程复杂化。服用双氢可待因和吗啡的患者入院后不久血浆药物浓度大幅升高（分别为184和60微克/升）。所有三名患者的肌病临床证据均不明显，一名患者在第7天的肌肉活检结果正常。
