Infertility poses a global challenge that impacts a significant proportion of the populace. Presently, there is a substantial emphasis on investigating the potential of probiotics and their derivatives, called postbiotics, as an alternative therapeutic strategy for addressing infertility. The term of "postbiotics" refers to compounds including peptides, enzymes, teichoic acids, and muropeptides derived from peptidoglycans, polysaccharides, proteins, and organic acids that are excreted by living bacteria or released after bacterial lysis. Postbiotics exhibit the capacity to enhance fertility in both men and women, with their impact on male reproductive function (specifically testicular function, semen quality, and prostate health) and female reproductive health (including modulation of vaginal microbiota and restoration thereof) being posited as potential mechanisms by which postbiotics may enhance fertility. This review highlights definitions of postbiotics, as well as their biological role in treatment of infertility.