Hoogkamp-Korstanje J A
Infection. 1985 Jan-Feb;13(1):39-42. doi: 10.1007/BF01643620.
The antimicrobial activity of six aminoglycosides against 927 clinical isolates was compared. Gentamicin and netilmicin were most active against Enterobacteriaceae, followed by tobramycin greater than dibekacin greater than amikacin greater than kanamycin. Tobramycin was most active against Pseudomonas aeruginosa, both mucoid and non-mucoid strains, followed by dibekacin greater than gentamicin greater than netilmicin greater than amikacin greater than kanamycin. Piperacillin-aminoglycoside combinations acted (partially) synergistically against 33-40% of the Enterobacteriaceae, 34-58% of non-mucoid strains of P. aeruginosa and 63-84% of the mucoid strains of P. aeruginosa (p less than 0.01). Piperacillin + gentamicin was the most synergistic combination against Enterobacteriaceae and non-mucoid strains of P. aeruginosa (p less than 0.05). The action against Staphylococcus aureus and Streptococcus faecalis was mostly indifferent. Antagonism was not observed. In treating gram-negative infections where tissue concentrations are less important, every aminoglycoside combination may be effective; for Pseudomonas lung infections in cystic fibrosis, piperacillin + gentamicin or tobramycin will remain the drugs of first choice.
比较了六种氨基糖苷类药物对927株临床分离菌的抗菌活性。庆大霉素和奈替米星对肠杆菌科细菌的活性最强，其次是妥布霉素大于地贝卡星大于阿米卡星大于卡那霉素。妥布霉素对铜绿假单胞菌（包括黏液型和非黏液型菌株）的活性最强，其次是地贝卡星大于庆大霉素大于奈替米星大于阿米卡星大于卡那霉素。哌拉西林-氨基糖苷类药物联合使用对33%-40%的肠杆菌科细菌、34%-58%的非黏液型铜绿假单胞菌菌株和63%-84%的黏液型铜绿假单胞菌菌株有（部分）协同作用（p<0.01）。哌拉西林+庆大霉素是对肠杆菌科细菌和非黏液型铜绿假单胞菌菌株最具协同作用的组合（p<0.05）。对金黄色葡萄球菌和粪肠球菌的作用大多不明显。未观察到拮抗作用。在治疗组织浓度不太重要的革兰阴性菌感染时，每种氨基糖苷类药物联合使用可能都有效；对于囊性纤维化患者的铜绿假单胞菌肺部感染，哌拉西林+庆大霉素或妥布霉素仍将是首选药物。
