Viotte G, Olier B, Morin J P, Godin M
Nouv Presse Med. 1982 Nov 18;11(46):3419-25.
In this study, we evaluate the nephrotoxic potential of dibekacin (D) compared to gentamicin (G), tobramycin (T), amikacin (A) and netilmicin (N). The mean features of aminoglycoside nephrotoxicity are: a lysosomal membrane fragilization, a lysosomal phospholipidosis characterized by a decrease activity of sphingomyelinase, an increase lysosomal volume with both an increase of individual size and an increase number of lysosomes, a cell necrosis and renal failure. We have quantified these parameters biochemically and morphometrically. We can classify, considering doses and durations, the aminoglycosides as gentamicin greater than or equal to netilmicin greater than dibekacin = tobramycin greater than amikacin for decreasing nephrotoxic incidence.
在本研究中，我们评估了地贝卡星（D）与庆大霉素（G）、妥布霉素（T）、阿米卡星（A）和奈替米星（N）相比的肾毒性潜力。氨基糖苷类肾毒性的平均特征为：溶酶体膜脆性增加、以鞘磷脂酶活性降低为特征的溶酶体磷脂沉积症、溶酶体体积增加，包括单个溶酶体大小增加和溶酶体数量增加、细胞坏死和肾衰竭。我们已通过生化和形态计量学方法对这些参数进行了量化。考虑到剂量和用药持续时间，我们可以将氨基糖苷类药物按降低肾毒性发生率的顺序分类为：庆大霉素≥奈替米星＞地贝卡星 = 妥布霉素＞阿米卡星。
