Höller H, Breves G, Schmitt R
Int J Vitam Nutr Res. 1979;49(4):391-5.
In seven experiments with two adult sheep a single dose of 35S-thiamin was injected intravenously. Blood and urine samples were taken at short intervals after dosing and analyzed for 35S-radioactivity. The data obtained were subjected to a curve fitting computer program. The disappearance of 35S-thiamin from blood followed a three-exponential function; the average half-times of the three components were 0.4, 3.7 and 93.7 minutes. Urinary excretion of the tracer was also three-exponential and amounted to 19--32% of the injected dose over 150 minutes.
在对两只成年绵羊进行的七项实验中，静脉注射了单剂量的35S-硫胺素。给药后短时间内采集血液和尿液样本，并分析其中的35S放射性。将获得的数据输入曲线拟合计算机程序。血液中35S-硫胺素的消失遵循三指数函数；三个成分的平均半衰期分别为0.4、3.7和93.7分钟。示踪剂的尿排泄也是三指数的，在150分钟内相当于注射剂量的19%-32%。
