Breves G, Schmitt R, Höller H
Int J Vitam Nutr Res. 1982;52(1):3-8.
Adult sheep received a single intravenous injection of 35S-thiamin. Blood and urine samples were taken at short intervals for the following 180 minutes and analyzed for 35S-radioactivity. Tracer disappearance from blood followed three-exponential functions. It was shown by computer simulation of different compartment models that a serial as well as a parallel three-compartment model would adequately describe 35S-thiamin disappearance from blood whereas a cyclic arrangement of the three compartments can be excluded. Total tracer excretion rates exceeding experimentally determined urinary excretion suggest the existence of a fourth compartment with nor or extremely small tracer return during the experimental period.
成年绵羊接受了一次35S-硫胺素的静脉注射。在接下来的180分钟内每隔短时间采集血液和尿液样本，并分析其中的35S放射性。示踪剂从血液中的消失遵循三个指数函数。通过对不同隔室模型的计算机模拟表明，串联以及并联的三室模型都能充分描述35S-硫胺素从血液中的消失情况，而三室的循环排列可以排除。超过实验测定尿排泄量的总示踪剂排泄率表明存在第四个隔室，在实验期间示踪剂返回该隔室的量极少或没有。
