Boddie A W, Wright K, Stephens L C, Yamanashi W S, Frazer J, McBride C M, Wallace S, Martin R G
Invest Radiol. 1985 Mar-Apr;20(2):159-65. doi: 10.1097/00004424-198503000-00012.
An animal model of partial hepatic artery occlusion and radiofrequency (RF)-induced hepatic hyperthermia was developed in the New Zealand white rabbit. Seventy-seven percent (10/13) of animals survived partial hepatic artery occlusion, 82% (41/50) survived RF-induced hepatic hyperthermia, and 66% (24/36) survived combined occlusion-hyperthermia. Mesenteric infarction secondary to inadvertent embolization of intestinal arteries was the principal cause of death in animals undergoing partial hepatic artery occlusion. Extrahepatic thermal toxicity appeared to be the major cause of death in animals subjected to hepatic hyperthermia or occlusion hyperthermia although some animals showed evidence of hepatic necrosis as well. Recent developments in our laboratory hold the promise that extrahepatic thermal toxicity can be eliminated by selectively focusing heat into the liver allowing exploration of the efficacy of occlusion-hyperthermia in controlling VX-2 tumors implanted in the rabbit liver.
在新西兰白兔中建立了部分肝动脉闭塞和射频（RF）诱导的肝脏高温动物模型。77%（10/13）的动物在部分肝动脉闭塞后存活，82%（41/50）的动物在RF诱导的肝脏高温后存活，66%（24/36）的动物在联合闭塞-高温后存活。部分肝动脉闭塞动物中，因肠动脉意外栓塞继发的肠系膜梗死是主要死亡原因。肝外热毒性似乎是接受肝脏高温或闭塞高温动物的主要死亡原因，尽管一些动物也有肝坏死的迹象。我们实验室的最新进展有望通过将热量选择性地聚焦到肝脏中来消除肝外热毒性，从而探索闭塞-高温在控制植入兔肝脏的VX-2肿瘤方面的疗效。
