Department of Frigidzone Medicine, College of High Altitude Military Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Chongqing, 400038, China.
Mol Nutr Food Res. 2024 Jan;68(1):e2300165. doi: 10.1002/mnfr.202300165. Epub 2023 Oct 27.
The study aims to investigate the role of the sulfur microbial diet in the survival of ovarian cancer (OC).
A prospective cohort study is conducted with 703 patients diagnosed with OC between 2015 and 2020. Diet information is collected using a validated food frequency questionnaire. Deaths are ascertained up to March 31, 2021, via the death registry linkage. During the follow-up period (median: 37.2 months, interquartile range: 24.7-50.2 months), 130 deaths are observed. A higher sulfur microbial diet score is significantly associated with an increased risk of all-cause mortality among OC patients (tertile 3 vs tertile 1: HR = 1.93, 95% CI = 1.11-3.35). Each 1-standard deviation increment in the sulfur microbial diet score increases the all-cause mortality risk by 33% (95% CI = 1.04-1.71). Stratified analysis shows that significant associations are found in OC patients diagnosed over 50 years of age, with body mass index ≥24 kg m , who changed their diet after diagnosis, or without residual lesions.
Adherence to the sulfur microbial diet, characterized by high intakes of red meats and processed meats, and low intakes of fruits, vegetables, and whole grains, is associated with poor survival in OC patients.
本研究旨在探讨硫微生物饮食在卵巢癌（OC）患者生存中的作用。
对 2015 年至 2020 年间诊断为 OC 的 703 名患者进行前瞻性队列研究。使用经过验证的食物频率问卷收集饮食信息。通过死亡登记链接，确定截至 2021 年 3 月 31 日的死亡情况。在随访期间（中位数：37.2 个月，四分位距：24.7-50.2 个月），观察到 130 例死亡。较高的硫微生物饮食评分与 OC 患者全因死亡率的增加显著相关（三分位 3 与三分位 1：HR=1.93，95%CI=1.11-3.35）。硫微生物饮食评分每增加 1 个标准差，全因死亡率风险增加 33%（95%CI=1.04-1.71）。分层分析显示，在年龄超过 50 岁、体重指数≥24kg/m2、诊断后改变饮食或无残留病变的 OC 患者中存在显著相关性。
高摄入红肉和加工肉、低摄入水果、蔬菜和全谷物的硫微生物饮食与 OC 患者的不良生存相关。
