Sugimoto Mitsuru, Takagi Tadayuki, Suzuki Rei, Asama Hiroyuki, Shimizu Hiroshi, Sato Kentaro, Ohira Rei, Nakamura Jun, Takasumi Mika, Kato Tsunetaka, Yanagita Takumi, Otsuka Mitsuru, Hikichi Takuto, Ohira Hiromasa
Department of Gastroenterology, School of Medicine, Fukushima Medical University, Fukushima, Fukushima 960-1295, Japan.
Department of Endoscopy, Fukushima Medical University Hospital, Fukushima, Fukushima 960-1295, Japan.
Exp Ther Med. 2025 Jan 20;29(3):53. doi: 10.3892/etm.2025.12803. eCollection 2025 Mar.
Endoscopic ultrasound-guided biliary drainage (EUS-BD) is performed as a second drainage method when endoscopic retrograde cholangiopancreatography-guided biliary drainage fails. There are several severe adverse events in EUS-BD, and avoiding technical failure is desirable. Although EUS-BD is a skilled endoscopic treatment, the appropriate conditions for EUS-BD beginners are not well known. The present study aimed to clarify the appropriate cases for EUS-BD beginners. The present retrospective cohort study included patients with malignant biliary obstruction who underwent EUS-BD, which was performed by beginners between March 2005 and June 2024. Factors associated with successful EUS-BD performed by beginners were evaluated by multivariate logistic regression analysis. The performance of each factor was evaluated via a receiver operating characteristic (ROC) curve. According to multivariate analysis, the diameter of the punctured bile duct was associated with successful EUS-BD performed by beginners (odds ratio, 1.34; 95% CI, 1.03-1.75; P=0.031). The area under the ROC curve for the diameter of the punctured bile duct was 0.79, and the cutoff value was 6.7 mm (71% sensitivity and 81.8% specificity). The diameter of the punctured bile duct might be associated with successful EUS-BD procedures performed by beginners. When a beginner performs EUS-BD, a diameter of the targeted bile duct >6.7 mm might be desirable for successful procedures.
当内镜逆行胰胆管造影引导下的胆管引流失败时,内镜超声引导下胆管引流(EUS-BD)作为第二种引流方法进行。EUS-BD存在几种严重不良事件,避免技术失败是可取的。尽管EUS-BD是一种需要技巧的内镜治疗方法,但EUS-BD初学者的合适条件尚不为人所知。本研究旨在明确EUS-BD初学者的合适病例。本项回顾性队列研究纳入了2005年3月至2024年6月期间由初学者进行EUS-BD的恶性胆管梗阻患者。通过多因素逻辑回归分析评估与初学者成功进行EUS-BD相关的因素。通过受试者工作特征(ROC)曲线评估每个因素的表现。根据多因素分析,穿刺胆管的直径与初学者成功进行EUS-BD相关(比值比,1.34;95%置信区间,1.03-1.75;P=0.031)。穿刺胆管直径的ROC曲线下面积为0.79,临界值为6.7mm(灵敏度71%,特异度81.8%)。穿刺胆管的直径可能与初学者成功进行EUS-BD操作相关。当初学者进行EUS-BD时,目标胆管直径>6.7mm可能有利于操作成功。