Chiral polymer-induced hydroxyapatite for promoting bone regeneration.

Chirality is one of the basic characteristics of living matter, yet the effect of chiral polymers on osteogenesis is seldom studied. Thus, it is necessary to deeply recognize the behaviors of chiral polymers in osteogenic processes, which can be beneficial for the development of bone repair materials. In this work, chiral hydroxyapatite (HAP) was constructed simply using poly(levorotatory/dextral-tartaric acid) as the guest of the chiral transfer system. We studied the influence of chiral HAPs on the migration and differentiation of pre-osteoblasts, and angiogenesis of endothelial cell in vitro. The results showed that poly(levorotatory-tartaric acid)-induced HAP did promote vascular remodeling and exhibited excellent impact on osteogenetic differentiation by improving the related gene and protein expression, whereas no significant change was observed in poly(dextral-tartaric acid) or poly(racemic-tartaric acid) induced HAP, respectively. This study highlighted the effects of chiral polymers on osteogenic potential, which laid the groundwork for the development of biomaterials for bone regeneration.