Bandyopadhyay Suritra, Forzano Joseph A, Dirak Musa, Chan Jefferson
Department of Chemistry, Cancer Center at Illinois and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, 61801 Illinois United States.
Department of Chemistry, Koç University, 34450 Istanbul, Türkiye.
JACS Au. 2025 Jan 15;5(1):42-54. doi: 10.1021/jacsau.4c01108. eCollection 2025 Jan 27.
Porphyrins, known as the "pigments of life", have evolved from their natural roles into versatile tools for biomedical applications. The development of activatable porphyrins has significantly expanded their utility, enabling precise responses to a carefully selected target analyte. These advances have broadened their use in imaging, diagnosis, and therapy. These capabilities are driven by activity-based sensing (ABS), which enhances the selectivity and sensitivity to various disease biomarkers. However, their design and implementation are intrinsically complex. This perspective provides an easy-to-follow roadmap that details how such molecules can be developed. Furthermore, we highlight recent progress in ABS-modified porphyrins, focusing on how specific modifications achieve these remarkable properties across various biomedical platforms. The ongoing evolution of activatable porphyrins holds great promise for the development of sophisticated, responsive systems, offering more effective diagnostic and therapeutic tools.
卟啉，被誉为“生命的色素”，已从其天然角色演变为生物医学应用的多功能工具。可激活卟啉的发展显著扩展了其用途，能够对精心挑选的目标分析物做出精确反应。这些进展拓宽了它们在成像、诊断和治疗方面的应用。这些能力是由基于活性的传感（ABS）驱动的，它提高了对各种疾病生物标志物的选择性和灵敏度。然而，它们的设计和实施本质上很复杂。本文提供了一个易于遵循的路线图，详细说明了如何开发此类分子。此外，我们强调了ABS修饰卟啉的最新进展，重点关注特定修饰如何在各种生物医学平台上实现这些卓越特性。可激活卟啉的不断发展为开发复杂的响应系统带来了巨大希望，提供了更有效的诊断和治疗工具。
