跨物种模拟心脏收缩协同性
Modeling cardiac contractile cooperativity across species.
作者信息
Childers Matthew Carter
机构信息
Department of Bioengineering, University of Washington, Seattle, WA, USA.
出版信息
J Gen Physiol. 2025 Mar 3;157(2). doi: 10.1085/jgp.202413722. Epub 2025 Jan 31.
Abstract
Phan and Fitzsimons (https://doi.org/10.1085/jgp.202413582) develop a new mathematical model of muscle contraction that explores cooperative mechanisms in small (murine) and large (porcine) myocardium.
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Modeling cardiac contractile cooperativity across species.跨物种模拟心脏收缩协同性
J Gen Physiol. 2025 Mar 3;157(2). doi: 10.1085/jgp.202413722. Epub 2025 Jan 31.
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Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium.模拟哺乳动物心肌中细肌丝近邻协同相互作用的影响。
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本文引用的文献
1
Modeling the effects of thin filament near-neighbor cooperative interactions in mammalian myocardium.模拟哺乳动物心肌中细肌丝近邻协同相互作用的影响。
J Gen Physiol. 2025 Mar 3;157(2). doi: 10.1085/jgp.202413582. Epub 2025 Jan 27.
2
The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and [Ca].肌球蛋白调节轻链磷酸化的结构和功能效应可通过肌节长度和 [Ca] 的增加而放大。
J Physiol. 2024 Oct;602(19):4941-4958. doi: 10.1113/JP286802. Epub 2024 Sep 16.
3
Multiscale modeling shows how 2'-deoxy-ATP rescues ventricular function in heart failure.多尺度模型显示 2'-脱氧-ATP 如何挽救心力衰竭中的心室功能。
Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2322077121. doi: 10.1073/pnas.2322077121. Epub 2024 Aug 22.
4
Myosin-binding protein H-like regulates myosin-binding protein distribution and function in atrial cardiomyocytes.肌球蛋白结合蛋白 H 样蛋白调节心房肌细胞中肌球蛋白结合蛋白的分布和功能。
Proc Natl Acad Sci U S A. 2023 Dec 19;120(51):e2314920120. doi: 10.1073/pnas.2314920120. Epub 2023 Dec 13.
5
Cryo-EM structure of the human cardiac myosin filament.人类心肌球蛋白丝的冷冻电镜结构。
Nature. 2023 Nov;623(7988):853-862. doi: 10.1038/s41586-023-06691-4. Epub 2023 Nov 1.
6
Structure of the native myosin filament in the relaxed cardiac sarcomere.心肌节段弛豫时天然肌球蛋白丝的结构。
Nature. 2023 Nov;623(7988):863-871. doi: 10.1038/s41586-023-06690-5. Epub 2023 Nov 1.
7
Cooperative mechanisms underlie differences in myocardial contractile dynamics between large and small mammals.合作机制是大型和小型哺乳动物心肌收缩动力学差异的基础。
J Gen Physiol. 2023 Nov 6;155(11). doi: 10.1085/jgp.202213315. Epub 2023 Sep 19.
8
Multiscale computational modeling of the effects of 2'-deoxy-ATP on cardiac muscle calcium handling.2'-脱氧三磷酸腺苷对心肌钙处理影响的多尺度计算建模
J Appl Phys. 2023 Aug 21;134(7):074905. doi: 10.1063/5.0157935. Epub 2023 Aug 16.
9
Muscle Mechanics and Thick Filament Activation: An Emerging Two-Way Interaction for the Vertebrate Striated Muscle Fine Regulation.肌肉力学与粗丝激活：脊椎动物横纹肌精细调节的新兴双向相互作用。
Int J Mol Sci. 2023 Mar 27;24(7):6265. doi: 10.3390/ijms24076265.
10
Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin.与肌球蛋白结合于肌动蛋白-原肌球蛋白的 ADP 释放相关的构象变化。
J Gen Physiol. 2023 Mar 6;155(3). doi: 10.1085/jgp.202213267. Epub 2023 Jan 12.
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