Landers Josh B, Allen Melissa, Oladele Ibrahim, Lowe Leah, Ali Nawab, Rainey Jacquie, Fletcher James, Landers Korben
Vasc Biol. 2025 Feb 17;7(1). doi: 10.1530/VB-24-0008. Print 2025 Jan 1.
Blood flow restriction exercise (BFRE) is a therapeutic approach traditionally used to facilitate muscular strength and hypertrophy. Emerging evidence has identified its benefits on other systems and metabolic processes. The emphasis of this study was to examine potential impact of BFRE on serum levels of tissue plasminogen activator (tPA). Eighteen healthy adults (nine males, nine females; mean age: 34.44 ± 9.97) were randomized into groups to perform cycling either with or without blood flow restriction (BFR). Blood samples were collected before and after exercise to analyze serum concentrations of tPA. Significance in tPA between exercise groups did not reach significance but did show a large effect size (0.14) in favor of the BFR group. The trend suggests that this study was underpowered to reach significance. Further research should continue examining the impact of BFRE on serum levels of tPA. This methodology could be adapted to other populations to increase generalizability of results.
血流限制训练（BFRE）是一种传统上用于促进肌肉力量和肥大的治疗方法。新出现的证据表明了其对其他系统和代谢过程的益处。本研究的重点是检查BFRE对组织纤溶酶原激活物（tPA）血清水平的潜在影响。18名健康成年人（9名男性，9名女性；平均年龄：34.44±9.97）被随机分组，分别进行有或无血流限制（BFR）的骑行。在运动前后采集血样，以分析tPA的血清浓度。运动组之间tPA的差异未达到显著水平，但确实显示出有利于BFR组的较大效应量（0.14）。这种趋势表明本研究的效能不足以达到显著水平。进一步的研究应继续检查BFRE对tPA血清水平的影响。这种方法可以应用于其他人群，以提高结果的普遍性。
