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成人小脑桥脑角畸胎瘤全切和次全切手术治疗:1例报告

Surgical management of cerebellopontine angle teratomas with total and subtotal approach in adults: A case report.

作者信息

Nakhutsrishvili Sopho, Gakhokia Otar, Basilashvili Ana, Metreveli Mia, Alphaidze Elene, Shalibashvili Revaz

机构信息

Faculty of Medicine, Petre Shotadze Tbilisi Medical Academy, Tbilisi, Georgia.

Department of Neurosurgery, Ingorokva High Medical Technologies University Clinic, Tbilisi, Georgia.

出版信息

Int J Surg Case Rep. 2025 Feb;127:110927. doi: 10.1016/j.ijscr.2025.110927. Epub 2025 Jan 22.

Abstract

INTRODUCTION

Germ cell tumors (GCTs) are neoplasms originating from either gonadal or extragonadal tissues. Primary central nervous system (CNS) GCTs are rare and categorized into germinomas and non-germinomatous germ cell tumors (NGGCTs), the latter including teratomas. Intracranial teratomas represent a small fraction (0.1-1.5 %) of all brain tumors, predominantly occurring in the pineal and sellar regions. Posterior fossa teratomas in adults are exceptionally rare.

CASE PRESENTATIONS

This study presents two cases of cerebellopontine angle (CPA) mature teratomas in adult patients. The first case involves a 26-year-old female with severe headaches, diagnosed via MRI with a left CPA mass extending to the C2 level, confirmed as a mature teratoma post-surgical resection. The second case features a 37-year-old male with an incidental finding of a right CPA mass, leading to subtotal resection due to proximity to critical brainstem structures.

DISCUSSION

CNS teratomas constitute 0.5-1 % of intracranial neoplasms.Typical locations include midline structures; however, CPA localization is rare. Diagnosis primarily relies on imaging modalities like MRI, supplemented by histopathological confirmation. Surgical resection remains the mainstay of treatment, with the extent of resection balancing tumor removal and preservation of neurological function.

CONCLUSION

CPA teratomas are rare but should be considered in the differential diagnosis of CPA masses. Effective management requires advanced imaging for accurate diagnosis and careful surgical planning to balance tumor removal with preservation of neurological function. These cases illustrate successful outcomes with tailored approaches, emphasizing the need for awareness and expertise in handling such uncommon tumors.

摘要

引言

生殖细胞肿瘤(GCTs)是起源于性腺或性腺外组织的肿瘤。原发性中枢神经系统(CNS)生殖细胞肿瘤较为罕见,可分为生殖细胞瘤和非生殖细胞性生殖细胞肿瘤(NGGCTs),后者包括畸胎瘤。颅内畸胎瘤占所有脑肿瘤的一小部分(0.1 - 1.5%),主要发生在松果体区和鞍区。成人后颅窝畸胎瘤极为罕见。

病例报告

本研究展示了两例成年患者小脑脑桥角(CPA)成熟畸胎瘤的病例。第一例为一名26岁女性,患有严重头痛,经MRI诊断为左侧CPA肿块,延伸至C2水平,术后切除证实为成熟畸胎瘤。第二例是一名37岁男性,偶然发现右侧CPA肿块,由于靠近关键脑干结构,进行了次全切除。

讨论

CNS畸胎瘤占颅内肿瘤的0.5 - 1%。典型位置包括中线结构;然而,CPA定位罕见。诊断主要依靠MRI等影像学检查,并辅以组织病理学确认。手术切除仍然是主要治疗方法,切除范围需平衡肿瘤切除与神经功能保留。

结论

CPA畸胎瘤罕见,但在CPA肿块的鉴别诊断中应予以考虑。有效的管理需要先进的影像学检查以进行准确诊断,并进行仔细的手术规划,以平衡肿瘤切除与神经功能保留。这些病例说明了采用定制方法取得的成功结果,强调了在处理此类罕见肿瘤时提高认识和专业技能的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37f2/11834126/5d5584b0a5d2/gr1.jpg

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