Xie Hui, Xie Sihui, Jiang Li, Lei Chenghong
College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, 541006, Guangxi, China.
Mikrochim Acta. 2025 Jan 31;192(2):116. doi: 10.1007/s00604-025-06967-8.
Ce-MOFs with ferrocenedicarboxylic acid ligands (Ce-FcDC) as a bifunctional nanozyme exhibited high peroxidase (POD)-mimicking activity and superoxide dismutase (SOD)-mimicking activity. HO was produced from catalytic hydrolysis of peroxymonosulfate (PMS) using Ce-FcDC as a catalyst. The growth of E. coli and S. aureus were synergistically and more effectively suppressed by PMS in the presence of Ce-FcDC, in comparison with the sole use of PMS or Ce-FcDc. Under the catalysis of Ce-FcDC as the POD-mimicking nanozyme, PMS could be activated by Ce-FcDC to produce SO and •OH and HO from the hydrolysis of PMS was further derivatized to O and •OH. Ce-FcDC as the SOD-mimicking nanozyme causes Oto form HO. The generation of O and •OH were confirmed using p-benzoquinone and isopropanol alcohol as the scavengers. The resulted SO, O, and •OH from combination of PMS with Ce-FcDC as an activator may have key roles for suppressing the growth of E. coli and S. aureus. This strategy could be an effective approach for suppressing the growth and preventing infections or pollutions of some other microbial cells as well.
具有二茂铁二羧酸配体的铈基金属有机框架材料（Ce-FcDC）作为一种双功能纳米酶，表现出高过氧化物酶（POD）模拟活性和超氧化物歧化酶（SOD）模拟活性。使用Ce-FcDC作为催化剂，通过过一硫酸盐（PMS）的催化水解产生羟基自由基（•OH）。与单独使用PMS或Ce-FcDc相比，在Ce-FcDC存在下，PMS对大肠杆菌和金黄色葡萄球菌的生长具有协同且更有效的抑制作用。在作为POD模拟纳米酶的Ce-FcDC催化下，PMS可被Ce-FcDC激活产生硫酸根自由基（SO₄•⁻）和•OH，并且PMS水解产生的•OH可进一步衍生为单线态氧（¹O₂）和•OH。作为SOD模拟纳米酶的Ce-FcDC使超氧阴离子（O₂•⁻）形成•OH。使用对苯醌和异丙醇作为清除剂证实了O₂•⁻和•OH的产生。PMS与作为活化剂的Ce-FcDC结合产生的SO₄•⁻、¹O₂和•OH可能在抑制大肠杆菌和金黄色葡萄球菌的生长中起关键作用。该策略也可能是抑制某些其他微生物细胞生长以及预防感染或污染的有效方法。
