State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin, 130022, P. R. China.
University of Chinese Academy of Sciences, Beijing, 100039, China.
Angew Chem Int Ed Engl. 2021 Feb 15;60(7):3469-3474. doi: 10.1002/anie.202012487. Epub 2020 Dec 14.
Metal-organic frameworks (MOFs) have sparked increasing interest in mimicking the structure and function of natural enzymes. However, their catalytic and therapeutic efficiency are unsatisfactory due to the relatively lower catalytic activity. Herein, inspired by nature, a MOF@COF nanozyme has been designed as a high-efficiency peroxidase mimic, with the metallic nodes of MOFs as active centres, the hierarchical nanocavities produced by the growth of covalent organic frameworks (COFs) as binding pockets to form tailored pore microenvironment around active sites for enriching and activating substrate molecules, to perform enhanced bacterial inhibition. Furthermore, the pseudopodia-like surface of the COFs "skin" enabled the system to catch the bacteria effectively for further amplifying the therapeutic efficiency of MOF-based nanozyme. We believe that the present study will not only facilitate the design of novel nanozymes, but also broaden the biological usage of MOF/COF-based hybrid materials.
金属-有机框架（MOFs）在模仿天然酶的结构和功能方面引起了越来越多的关注。然而，由于相对较低的催化活性，它们的催化和治疗效率并不令人满意。受自然启发，本文设计了一种 MOF@COF 纳米酶作为高效过氧化物酶模拟物，其中 MOFs 的金属节点作为活性中心，由共价有机框架（COFs）生长产生的分级纳米腔作为结合口袋，形成针对活性位点的定制孔微环境，以富集和激活底物分子，从而增强细菌抑制作用。此外，COFs“皮肤”的伪足样表面使该系统能够有效地捕获细菌，从而进一步提高基于 MOF 的纳米酶的治疗效率。我们相信，本研究不仅将促进新型纳米酶的设计，而且还将拓宽基于 MOF/COF 的杂化材料的生物学用途。
