de Almeida Lucivalda Viegas, Santos-de-Araújo Aldair Darlan, da Silva Luís Cláudio Nascimento, Santos Patricia Martins, Maia Mariana Campos, Frutuoso Victória Pereira, Rocha Daniel Santos, Rêgo Adriana Sousa, Bassi-Dibai Daniela
Postgraduate Program in Programs Management and Health Services, Universidade Ceuma, Josué Montello, number 1, São Luís, 65075-120, MA, Brazil.
Postgraduate Program in Physical Therapy, Department of Physical Therapy, Universidade Federal de São Carlos, São Carlos, SP, Brazil.
BMC Cardiovasc Disord. 2025 Jan 31;25(1):69. doi: 10.1186/s12872-025-04523-z.
The association between plasma lipids, nitric oxide (NO) and cardiovascular risk has been well documented in the literature, however, the association between these outcomes and heart rate variability (HRV) in COVID-19 remains incipient as there is no scientific evidence that has investigated this outcome.
Investigate whether metabolic outcomes may be associated with cardiac autonomic behavior arising from short-term HRV variables in non-hospitalized mild post-COVID individuals.
This is a cross-sectional study. Individuals of both sexes, aged ≥ 18 years, who tested positive for SARS-CoV-2 according to the RT-PCR test, without the need for hospitalization, were included. The HRV was collected in the supine position for at least 10 min for later analysis in the Kubios software. Metabolic outcomes [high density lipoprotein (HDL) (mg/dL), cholesterol (mg/dL), triglycerides (mg/dL) and NO (µmol/L)] were collected through a blood sample.
Seventy-three individuals were included (post-COVID = 32; control = 41). HRV was worse in the post-COVID group when compared to the control group (p < 0.05). Cholesterol, HDL, triglycerides and NO showed significant correlations with HRV indices. Regression models indicated that cholesterol and triglycerides, as well as NO, explain up to 30.3% of the variations in certain HRV indices, suggesting an impact of metabolic outcomes on autonomic modulation.
There is a relationship between plasma lipids, NO and HRV in non-hospitalized individuals with mild COVID-19. Metabolic outcomes are associated and explain between 16.6% and 30.30% of certain variables of resting HRV in post-COVID individuals.
Not applicable.
血浆脂质、一氧化氮（NO）与心血管风险之间的关联在文献中已有充分记载，然而，在新冠病毒病（COVID-19）中，这些结果与心率变异性（HRV）之间的关联仍处于初始阶段，因为尚无科学证据对这一结果进行研究。
调查在非住院的轻症COVID后个体中，代谢结果是否可能与短期HRV变量引起的心脏自主行为有关。
这是一项横断面研究。纳入年龄≥18岁、根据逆转录聚合酶链反应（RT-PCR）检测SARS-CoV-2呈阳性且无需住院的男女个体。HRV在仰卧位收集至少10分钟，随后在Kubios软件中进行分析。代谢结果[高密度脂蛋白（HDL）（mg/dL）、胆固醇（mg/dL）、甘油三酯（mg/dL）和NO（µmol/L）]通过血样收集。
纳入73名个体（COVID后组=32名；对照组=41名）。与对照组相比，COVID后组的HRV较差（p<0.05）。胆固醇、HDL、甘油三酯和NO与HRV指标显示出显著相关性。回归模型表明，胆固醇、甘油三酯以及NO可解释某些HRV指标高达30.3%的变化，提示代谢结果对自主神经调节有影响。
在非住院的轻症COVID-19个体中，血浆脂质、NO与HRV之间存在关联。代谢结果与COVID后个体静息HRV的某些变量相关，并可解释16.6%至30.30%的变化。
不适用。
