Karki Bhishma, Pal Amrindra, Dhiman Gaurav, Ahmed Mohammad Z
Department of Physics, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu, 44600, Nepal.
National Research Council Nepal, New Baneshwor-10, Kathmandu, 44600, Nepal.
Mikrochim Acta. 2025 Feb 1;192(2):126. doi: 10.1007/s00604-025-06983-8.
One of the primary causes of cancer-related mortality on a global scale is colorectal cancer. Early colorectal cancer detection can stop the disease from progressing and save lives. Detection of colorectal cancer at an early stage yields significant financial savings, lowers mortality rates, and allows for a broader range of less invasive, more effective treatment options, thereby improving patient outcomes. The copper (Cu), carbon nanotube (CNT), and Hafnium Diselenide (HfSe) with CaF prism-based structure have been proposed for colorectal and other cancer detection. The proposed sensor can detect the refractive index (RI) of the sensing medium (SM) between 1.33 and 1.35. The optimal thickness of Cu, CNT, and HfSe has been taken at 41nm, 1nm, and 2nm, respectively. At optimal structure have been determined the sensitivity, detection accuracy (DA), and figure of merit (FoM). The maximum sensitivity 356.66deg/RIU is attained at RI of SM 1.33-1.35. For the detection of colorectal cancer, the sensitivity, DA, and FoM of 387.60deg/RIU, 0.253/deg, and 98.6/RIU, respectively, are obtained. By comparison with the reported work in the literature, the results provide a significant improvement. At optimal structure have been determined the sensitivity, DA, and FoM.
全球范围内，结直肠癌是癌症相关死亡的主要原因之一。早期检测结直肠癌可以阻止疾病进展并挽救生命。早期检测结直肠癌可节省大量资金，降低死亡率，并提供更广泛的侵入性较小、更有效的治疗选择，从而改善患者预后。基于CaF棱镜结构的铜（Cu）、碳纳米管（CNT）和二硒化铪（HfSe）已被用于结直肠癌及其他癌症的检测。所提出的传感器能够检测传感介质（SM）在1.33至1.35之间的折射率（RI）。Cu、CNT和HfSe的最佳厚度分别取为41nm、1nm和2nm。在最佳结构下确定了灵敏度、检测精度（DA）和品质因数（FoM）。在SM的RI为1.33 - 1.35时，获得最大灵敏度356.66deg/RIU。对于结直肠癌的检测，分别获得灵敏度、DA和FoM为387.60deg/RIU、0.253/deg和98.6/RIU。与文献中报道的数据相比，结果有显著改善。在最佳结构下确定了灵敏度、DA和FoM。
