Zhang Yanbo, Luo Kai, Peters Brandilyn A, Mossavar-Rahmani Yasmin, Moon Jee-Young, Wang Yi, Daviglus Martha L, Van Horn Linda, McClain Amanda C, Cordero Christina, Floyd James S, Yu Bing, Walker Ryan W, Burk Robert D, Kaplan Robert C, Qi Qibin
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Institute for Minority Health Research, University of Illinois Chicago, Chicago, IL, USA.
Cell Metab. 2025 Mar 4;37(3):578-591.e4. doi: 10.1016/j.cmet.2024.12.004. Epub 2025 Jan 31.
No population-based studies examined gut microbiota and related metabolites associated with sugar-sweetened beverage (SSB) intake among US adults. In this cohort of US Hispanic/Latino adults, higher SSB intake was associated with nine gut bacterial species, including lower abundances of several short-chain-fatty-acid producers, previously shown to be altered by fructose and glucose in animal studies, and higher abundances of fructose- and glucose-utilizing Clostridium bolteae and Anaerostipes caccae. Fifty-six serum metabolites were correlated with SSB intake and a gut microbiota score based on these SSB-related species in consistent directions. These metabolites were clustered into several modules, including a glycerophospholipid module, two modules comprising branched-chain amino acid (BCAA) and aromatic amino acid (AAA) derivatives from microbial metabolism, etc. Higher glycerophospholipid and BCAA derivative levels and lower AAA derivative levels were associated with higher incident diabetes risk during follow-up. These findings suggest a potential role of gut microbiota in the association between SSB intake and diabetes.
在美国成年人中，尚无基于人群的研究考察与含糖饮料（SSB）摄入相关的肠道微生物群及相关代谢物。在这一美国西班牙裔/拉丁裔成年人群体中，较高的SSB摄入量与9种肠道细菌种类相关，包括几种短链脂肪酸产生菌的丰度较低，此前在动物研究中已表明这些细菌会被果糖和葡萄糖改变，以及利用果糖和葡萄糖的博氏梭菌（Clostridium bolteae）和粪厌氧棒状菌（Anaerostipes caccae）的丰度较高。56种血清代谢物与SSB摄入量以及基于这些与SSB相关菌种的肠道微生物群评分呈一致方向的相关性。这些代谢物被聚类为几个模块，包括一个甘油磷脂模块、两个由微生物代谢产生的支链氨基酸（BCAA）和芳香族氨基酸（AAA）衍生物组成的模块等。在随访期间，较高的甘油磷脂和BCAA衍生物水平以及较低的AAA衍生物水平与较高的糖尿病发病风险相关。这些发现提示肠道微生物群在SSB摄入与糖尿病之间的关联中可能发挥作用。
