水凝胶增强间充质干细胞及其衍生外泌体在年龄相关性肌肉骨骼疾病再生医学中的应用。

Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases.

作者信息

Liu Lixin, Chen Siwen, Song Yantao, Cui Longwei, Chen Yiman, Xia Jiangli, Fan Yibo, Yang Liqun, Yang Lina

机构信息

Departments of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, PR China.

Research Center for Biomedical Materials, Shenyang Key Laboratory of Biomedical Polymers, Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, Shenyang 110004, PR China; Center for Molecular Science and Engineering, College of Science, Northeastern University, Shenyang 110819, PR China.

出版信息

Pharmacol Res. 2025 Mar;213:107618. doi: 10.1016/j.phrs.2025.107618. Epub 2025 Jan 30.

DOI:10.1016/j.phrs.2025.107618

PMID:39892438

Abstract

As the population ages, musculoskeletal diseases (MSK) have emerged as a significant burden for individuals, healthcare systems, and social care systems. Recently, regenerative medicine has exhibited vast potential in age-related MSK, with mesenchymal stromal cells (MSCs) and their derived exosomes (Exos) therapies showing distinct advantages. However, these therapies face several limitations, including issues related to ensuring stability and effective distribution within the body. Hydrogels, acting as an ideal carrier, can enhance the therapeutic effects and application range of MSCs and Exos derived from MSCs (MSC-Exos). Therefore, this review comprehensively summarizes the application progress of MSCs and MSC-Exos combined with hydrogels in age-related MSK disease research. It aims to provide a detailed perspective, showcasing the functional enhancement of MSCs and MSC-Exos when incorporated into hydrogels. Additionally, this review explores their potential and challenges in treating age-related MSK diseases, offering references for future research directions and potential innovative strategies.

摘要

随着人口老龄化，肌肉骨骼疾病（MSK）已成为个人、医疗保健系统和社会护理系统的重大负担。最近，再生医学在与年龄相关的肌肉骨骼疾病中展现出巨大潜力，间充质基质细胞（MSCs）及其衍生的外泌体（Exos）疗法显示出明显优势。然而，这些疗法面临一些局限性，包括与确保体内稳定性和有效分布相关的问题。水凝胶作为理想的载体，可以增强MSCs和源自MSCs的外泌体（MSC-Exos）的治疗效果和应用范围。因此，本综述全面总结了MSCs和MSC-Exos与水凝胶联合应用在与年龄相关的肌肉骨骼疾病研究中的进展。其目的是提供详细的视角，展示MSCs和MSC-Exos融入水凝胶时的功能增强。此外，本综述探讨了它们在治疗与年龄相关的肌肉骨骼疾病中的潜力和挑战，为未来的研究方向和潜在的创新策略提供参考。