Aikawa Gen, Hoshino Tetsuya, Sakuramoto Hideaki, Ouchi Akira, Ikeda Mitsuki, Kotani Misaki, Okamoto Saiko, Enomoto Yuki, Shimojo Nobutake, Inoue Yoshiaki
College of Nursing, Kanto Gakuin University, Yokohama, Kanagawa, Japan; Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan; Department of Intensive Care, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan.
J Crit Care. 2025 Jun;87:155031. doi: 10.1016/j.jcrc.2025.155031. Epub 2025 Feb 1.
This study aimed to evaluate the feasibility of using electrogastrography (EGG)/electroenterography (EEnG) to quantitatively visualize gastrointestinal (GI) motor function in critically ill patients.
EGG/EEnG were performed at baseline and before and after nutrition in critically ill patients with mechanical ventilation. Enteral nutrition varied in content. Dominant frequency (DF), dominant power (DP), and power ratio (PR) were calculated and compared with those from healthy controls (previous study; n = 50).
Data from 20 % of patients were unstable and could not be analyzed. Of the 54 patients analyzed, 41 were on enteral nutrition, and their age and body mass index differed from controls. Gastric DF differed significantly between critically ill patients and controls (p < 0.001). No significant difference was noted in gastric log DP between pre- and post-prandial periods in critically ill patients (2.79 vs 2.86, p = 0.328), but controls showed a significant increase (3.04 vs 3.22, p = 0.009). Critically ill patients had lower gastric log DP than controls (pre-prandial p = 0.038; post-prandial p = 0.003). In the small intestine, log DP did not differ significantly between pre- and post-prandial periods in critically ill patients (1.45 vs 1.52, p = 0.181), but controls showed a significant increase (1.70 vs 1.86, p < 0.001). Critically ill patients had lower small intestinal log DP than controls (pre-prandial p = 0.004; post-prandial p < 0.001). PR was inferior in critically ill patients than in controls.
EGG/EEnG could enable quantitative visualization of GI motor function in critically ill patients. Larger studies can determine the association of GI symptoms with risk factors and prognostic factors.
本研究旨在评估使用胃电图（EGG）/肠电图（EEnG）定量可视化危重症患者胃肠道（GI）运动功能的可行性。
对机械通气的危重症患者在基线时以及营养支持前后进行EGG/EEnG检查。肠内营养的内容各不相同。计算主导频率（DF）、主导功率（DP）和功率比（PR），并与健康对照者（既往研究；n = 50）的数据进行比较。
20%患者的数据不稳定，无法进行分析。在分析的54例患者中，41例接受肠内营养，他们的年龄和体重指数与对照组不同。危重症患者与对照组的胃DF差异显著（p < 0.001）。危重症患者餐前和餐后胃log DP无显著差异（2.79对2.86，p = 0.328），但对照组有显著增加（3.04对3.22，p = 0.009）。危重症患者的胃log DP低于对照组（餐前p = 0.038；餐后p = 0.003）。在小肠，危重症患者餐前和餐后log DP无显著差异（1.45对1.52，p = 0.181），但对照组有显著增加（1.70对1.86，p < 0.001）。危重症患者的小肠log DP低于对照组（餐前p = 0.004；餐后p < 0.001）。危重症患者的PR低于对照组。
EGG/EEnG能够定量可视化危重症患者的胃肠道运动功能。更大规模的研究可以确定胃肠道症状与危险因素和预后因素之间的关联。
