韩国红参对氧化应激诱导的人发损伤的保护作用。
Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair.
作者信息
Jung Seung-Won, Pi Long-Quan, Jeon Jae Joon, Kim You Hyun, Lee Solam, Lee Won-Soo
机构信息
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Department of Dermatology, Yanbian University Hospital, Yanji, China.
出版信息
Ann Dermatol. 2025 Feb;37(1):1-11. doi: 10.5021/ad.24.047.
BACKGROUND
Oxidative stress causes fatal damage to follicular keratinocytes (FKCs) and is a common pathophysiology of many hair disorders.
OBJECTIVE
This study investigated the protective effects of Red ginseng extract (RGE) and its main ginsenosides against oxidative hair damage using an organ model of human hair follicles.
METHODS
We examined whether RGE and its constituent ginsenosides could prevent oxidative damage induced by H₂O₂ in FKCs by suppressing apoptosis and promoting hair growth.
RESULTS
RGE and its main ginsenoside, G-Rb1, significantly inhibited reactive oxygen species production and apoptosis in FKCs. Furthermore, they effectively alleviated the inhibition of hair growth induced by oxidative damage and inhibited the transition of hair from the anagen to the telogen stage. The hair cycle and apoptosis were associated with the modulation of p53 and Bax/Bcl2 signaling.
CONCLUSION
RGE and G-Rb1 can effectively mitigate the oxidative damage caused by FKCs, thereby affecting hair growth and hair cycles.
背景
氧化应激会对毛囊角质形成细胞（FKCs）造成致命损伤，是多种毛发疾病常见的病理生理学机制。
目的
本研究使用人毛囊器官模型，探究红参提取物（RGE）及其主要人参皂苷对毛发氧化损伤的保护作用。
方法
我们通过抑制细胞凋亡和促进毛发生长，研究RGE及其成分人参皂苷是否能预防H₂O₂诱导的FKCs氧化损伤。
结果
RGE及其主要人参皂苷G-Rb1显著抑制FKCs中活性氧的产生和细胞凋亡。此外，它们有效缓解了氧化损伤诱导的毛发生长抑制，并抑制毛发从生长期向休止期的转变。毛发周期和细胞凋亡与p53以及Bax/Bcl2信号通路的调节有关。
结论
RGE和G-Rb1能有效减轻FKCs引起的氧化损伤，从而影响毛发生长和毛发周期。
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