Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department and 4th Medical Center, PLA General Hospital and PLA Medical College; PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration; Research Unit of Trauma Care, Tissue Repair and Regeneration, Chinese Academy of Medical Sciences, 2019RU051, Beijing, 100048, People's Republic of China.
Signal Transduct Target Ther. 2021 Feb 17;6(1):66. doi: 10.1038/s41392-020-00441-y.
The hair follicle (HF) is a highly conserved sensory organ associated with the immune response against pathogens, thermoregulation, sebum production, angiogenesis, neurogenesis and wound healing. Although recent advances in lineage-tracing techniques and the ability to profile gene expression in small populations of cells have increased the understanding of how stem cells operate during hair growth and regeneration, the construction of functional follicles with cycling activity is still a great challenge for the hair research field and for translational and clinical applications. Given that hair formation and cycling rely on tightly coordinated epithelial-mesenchymal interactions, we thus review potential cell sources with HF-inducive capacities and summarize current bioengineering strategies for HF regeneration with functional restoration.
毛囊是一种与免疫反应、体温调节、皮脂产生、血管生成、神经发生和伤口愈合有关的高度保守的感觉器官。尽管谱系追踪技术的最新进展以及对小群体细胞中基因表达进行分析的能力提高了人们对干细胞在头发生长和再生过程中如何运作的理解，但构建具有循环活性的功能性毛囊仍然是毛发研究领域以及转化和临床应用的巨大挑战。鉴于毛发的形成和循环依赖于紧密协调的上皮-间充质相互作用，因此我们回顾了具有毛囊诱导能力的潜在细胞来源，并总结了当前具有功能恢复的毛囊再生的生物工程策略。
