Mullen T L, Muller M, Van Bruggen J T
J Gen Physiol. 1985 Mar;85(3):347-63. doi: 10.1085/jgp.85.3.347.
This study presents experiments related to the role of solvent drag and solute drag in the transmembrane movement of nonelectrolytes in a perfused rat intestine preparation. Conditions were chosen to simulate the effects of luminal hyperosmolarity on the permeability of tracer solutes. Data are presented on net water flux, transepithelial potentials, and lumen-to-blood and blood-to-lumen tracer solute movements during control electrolyte perfusion and after making the perfusate hyperosmotic. The results indicate that both solvent drag and solute drag can play significant roles in the transepithelial movement of solute and solute permeabilities in the rat ileum preparation. It is suggested that the potential roles of solvent drag and solute drag should be accounted for or considered during the characterization of the mechanisms of biological membrane function.
本研究展示了与溶剂拖曳和溶质拖曳在灌注大鼠肠道制剂中无电解质跨膜运动中的作用相关的实验。选择相关条件以模拟管腔高渗对示踪溶质通透性的影响。给出了在对照电解质灌注期间以及使灌注液变为高渗后，净水通量、跨上皮电位以及管腔到血液和血液到管腔的示踪溶质运动的数据。结果表明，在大鼠回肠制剂中，溶剂拖曳和溶质拖曳在溶质的跨上皮运动和溶质通透性方面均能发挥重要作用。建议在表征生物膜功能机制的过程中，应考虑或重视溶剂拖曳和溶质拖曳的潜在作用。
