Acır İbrahim, Sezen Ahmetcan, Aygün Murat Serhat, Altıntaş Ayşe
Bakırköy Dr Sadi Konuk Training and Research Hospital, Department of Neurology, Istanbul/Türkiye.
Koç University, Faculty of Medicine, Istanbul/Türkiye.
Mult Scler J Exp Transl Clin. 2025 Jan 31;11(1):20552173241312534. doi: 10.1177/20552173241312534. eCollection 2025 Jan-Mar.
SLIPPERS (Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids) is a rare variant of a syndrome called CLIPPERS (Chronic Lymphocytic Inflammation with Ponsine Perivascular Enhancement Responsive to Steroids). SLIPPERS is characterized by distinct supratentorial lesions that share radiological and pathological characteristics with CLIPPERS. The ongoing issue is whether these syndromes should be considered as a distinct disease entity or simply a form for a variety of underlying conditions such as granulomatosis, vasculitis, and infectious diseases.
We present a unique case of SLIPPERS observed in a 26-year-old woman with no notable medical or familial background. Laboratory findings ruled out certain diseases from the list of differentials and cranial MRI showed T2 hyperintense areas with linear-patchy enhancements, a pattern consistent with SLIPPERS syndrome. Consequently, patient was diagnosed with SLIPPERS syndrome and received methylprednisolone therapy.
Both SLIPPERS and CLIPPERS are complicated syndromes posing diagnostic challenges and requiring careful investigation to avoid misdiagnosis. Following a thorough differential diagnosis, appropriate treatment can be initiated, and follow-up is required.
SLIPPERS（幕上淋巴细胞性炎症伴实质血管周围强化且对类固醇有反应）是一种名为CLIPPERS（慢性淋巴细胞性炎症伴脑桥血管周围强化且对类固醇有反应）综合征的罕见变体。SLIPPERS的特征是独特的幕上病变，这些病变与CLIPPERS具有相同的放射学和病理学特征。目前的问题是，这些综合征应被视为一种独特的疾病实体，还是仅仅是各种潜在疾病（如肉芽肿病、血管炎和传染病）的一种形式。
我们报告了一例在一名无明显病史或家族史的26岁女性中观察到的SLIPPERS独特病例。实验室检查结果排除了鉴别诊断清单中的某些疾病，头颅磁共振成像显示T2高信号区伴有线性斑片状强化，这一模式与SLIPPERS综合征一致。因此，该患者被诊断为SLIPPERS综合征并接受了甲泼尼龙治疗。
SLIPPERS和CLIPPERS都是复杂的综合征，带来诊断挑战，需要仔细检查以避免误诊。经过全面的鉴别诊断后，可以开始适当的治疗，并需要进行随访。
