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1
Perspective: Current Scientific Evidence and Research Strategies in the Role of Almonds in Cardiometabolic Health.观点:杏仁在心脏代谢健康中的作用的当前科学证据与研究策略
Curr Dev Nutr. 2024 Nov 28;9(1):104516. doi: 10.1016/j.cdnut.2024.104516. eCollection 2025 Jan.
2
The Effects of Almond Consumption on Cardiovascular Health and Gut Microbiome: A Comprehensive Review.杏仁摄入对心血管健康和肠道微生物组的影响:全面综述。
Nutrients. 2024 Jun 20;16(12):1964. doi: 10.3390/nu16121964.
3
Effects of daily almond consumption on cardiometabolic risk and abdominal adiposity in healthy adults with elevated LDL-cholesterol: a randomized controlled trial.每日食用杏仁对低密度脂蛋白胆固醇升高的健康成年人心脏代谢风险和腹部肥胖的影响:一项随机对照试验。
J Am Heart Assoc. 2015 Jan 5;4(1):e000993. doi: 10.1161/JAHA.114.000993.
4
Snacking on whole almonds for 6 weeks improves endothelial function and lowers LDL cholesterol but does not affect liver fat and other cardiometabolic risk factors in healthy adults: the ATTIS study, a randomized controlled trial.连续 6 周食用整粒杏仁可改善内皮功能,降低 LDL 胆固醇,但不会影响健康成年人的肝脂肪和其他心血管代谢风险因素:ATTIS 研究,一项随机对照试验。
Am J Clin Nutr. 2020 Jun 1;111(6):1178-1189. doi: 10.1093/ajcn/nqaa100.
5
Effect of Almond Consumption on Metabolic Risk Factors-Glucose Metabolism, Hyperinsulinemia, Selected Markers of Inflammation: A Randomized Controlled Trial in Adolescents and Young Adults.食用杏仁对代谢风险因素——葡萄糖代谢、高胰岛素血症、炎症相关指标的影响:一项针对青少年和青年的随机对照试验。
Front Nutr. 2021 Jun 24;8:668622. doi: 10.3389/fnut.2021.668622. eCollection 2021.
6
Chronic almond nut snacking alleviates perceived muscle soreness following downhill running but does not improve indices of cardiometabolic health in mildly overweight, middle-aged, adults.长期食用杏仁零食可缓解下坡跑后感觉到的肌肉酸痛,但对轻度超重的中年成年人的心脏代谢健康指标并无改善作用。
Front Nutr. 2024 Jan 8;10:1298868. doi: 10.3389/fnut.2023.1298868. eCollection 2023.
7
A Comprehensive Review of Almond Clinical Trials on Weight Measures, Metabolic Health Biomarkers and Outcomes, and the Gut Microbiota.杏仁临床研究综述:体重指标、代谢健康生物标志物和结果,以及肠道微生物组。
Nutrients. 2021 Jun 8;13(6):1968. doi: 10.3390/nu13061968.
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Almond consumption improved glycemic control and lipid profiles in patients with type 2 diabetes mellitus.杏仁的摄入改善了 2 型糖尿病患者的血糖控制和血脂谱。
Metabolism. 2011 Apr;60(4):474-9. doi: 10.1016/j.metabol.2010.04.009. Epub 2010 May 23.
9
Effects of almond consumption on the reduction of LDL-cholesterol: a discussion of potential mechanisms and future research directions.杏仁摄入对降低 LDL 胆固醇的影响:潜在机制的讨论及未来研究方向。
Nutr Rev. 2011 Apr;69(4):171-85. doi: 10.1111/j.1753-4887.2011.00383.x.
10
The effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes: A systematic review and meta-analysis.杏仁摄入对心脏代谢危险因素、炎症标志物和肝酶的影响:一项系统评价和荟萃分析。
Phytother Res. 2022 Dec;36(12):4325-4344. doi: 10.1002/ptr.7622. Epub 2022 Nov 4.

本文引用的文献

1
The Effects of Almond Consumption on Cardiovascular Health and Gut Microbiome: A Comprehensive Review.杏仁摄入对心血管健康和肠道微生物组的影响:全面综述。
Nutrients. 2024 Jun 20;16(12):1964. doi: 10.3390/nu16121964.
2
Almond supplementation on appetite measures, body weight, and body composition in adults: A systematic review and dose-response meta-analysis of 37 randomized controlled trials.杏仁补充剂对成年人食欲测量、体重和身体成分的影响:37 项随机对照试验的系统评价和剂量反应荟萃分析。
Obes Rev. 2024 May;25(5):e13711. doi: 10.1111/obr.13711. Epub 2024 Feb 13.
3
Premeal almond load decreases postprandial glycaemia, adiposity and reversed prediabetes to normoglycemia: A randomized controlled trial.餐前食用杏仁可降低餐后血糖、肥胖,并将糖尿病前期逆转至正常血糖水平:一项随机对照试验。
Clin Nutr ESPEN. 2023 Apr;54:12-22. doi: 10.1016/j.clnesp.2022.12.028. Epub 2022 Dec 29.
4
Beneficial effects of premeal almond load on glucose profile on oral glucose tolerance and continuous glucose monitoring: randomized crossover trials in Asian Indians with prediabetes.餐前杏仁负荷对口服葡萄糖耐量和连续血糖监测的血糖谱的有益影响:在有前驱糖尿病的亚洲印度人中进行的随机交叉试验。
Eur J Clin Nutr. 2023 May;77(5):586-595. doi: 10.1038/s41430-023-01263-1. Epub 2023 Feb 2.
5
Effect of almond consumption on insulin sensitivity and serum lipids among Asian Indian adults with overweight and obesity- A randomized controlled trial.食用杏仁对超重和肥胖的亚洲印度成年人胰岛素敏感性和血脂的影响——一项随机对照试验。
Front Nutr. 2023 Jan 10;9:1055923. doi: 10.3389/fnut.2022.1055923. eCollection 2022.
6
The effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes: A systematic review and meta-analysis.杏仁摄入对心脏代谢危险因素、炎症标志物和肝酶的影响:一项系统评价和荟萃分析。
Phytother Res. 2022 Dec;36(12):4325-4344. doi: 10.1002/ptr.7622. Epub 2022 Nov 4.
7
synDNA-a Synthetic DNA Spike-in Method for Absolute Quantification of Shotgun Metagenomic Sequencing.synDNA—一种用于 shotgun 宏基因组测序绝对定量的合成 DNA Spike-in 方法。
mSystems. 2022 Dec 20;7(6):e0044722. doi: 10.1128/msystems.00447-22. Epub 2022 Nov 1.
8
The impact of almonds and almond processing on gastrointestinal physiology, luminal microbiology, and gastrointestinal symptoms: a randomized controlled trial and mastication study.杏仁及其加工方式对胃肠道生理学、腔道微生物群和胃肠道症状的影响:一项随机对照试验和咀嚼研究。
Am J Clin Nutr. 2022 Dec 19;116(6):1790-1804. doi: 10.1093/ajcn/nqac265.
9
Almond Consumption for 8 Weeks Altered Host and Microbial Metabolism in Comparison to a Control Snack in Young Adults.连续 8 周食用杏仁改变了青年人体内宿主和微生物的代谢,与对照零食相比。
J Am Nutr Assoc. 2023 Mar-Apr;42(3):242-254. doi: 10.1080/07315724.2021.2025168. Epub 2022 Feb 23.
10
The effect of almond intake on glycemic control: A systematic review and dose-response meta-analysis of randomized controlled trials.杏仁摄入量对血糖控制的影响:随机对照试验的系统评价和剂量反应荟萃分析。
Phytother Res. 2022 Jan;36(1):395-414. doi: 10.1002/ptr.7328. Epub 2021 Nov 29.

观点:杏仁在心脏代谢健康中的作用的当前科学证据与研究策略

Perspective: Current Scientific Evidence and Research Strategies in the Role of Almonds in Cardiometabolic Health.

作者信息

Trumbo Paula R, Ard Jamy, Bellisle France, Drewnowski Adam, Gilbert Jack A, Kleinman Ronald, Misra Anoop, Sievenpiper John, Tahiri Maha, Watson Karol E, Hill James

机构信息

Paula R. Trumbo Consulting, Mount Pleasant, SC, United States.

School of Health Sciences, Liberty University, Lynchburg, VA, United States.

出版信息

Curr Dev Nutr. 2024 Nov 28;9(1):104516. doi: 10.1016/j.cdnut.2024.104516. eCollection 2025 Jan.

DOI:10.1016/j.cdnut.2024.104516
PMID:39896730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11786730/
Abstract

Almonds are consumed by individuals around the world. Because almonds are rich in protein, unsaturated fatty acids, and fiber, a significant amount of research has been conducted on their role in affecting various cardiometabolic endpoints (body weight, blood pressure, blood cholesterol levels, and glycemic response). The most current meta-analyses on almond consumption and various health-related endpoints suggest that almond consumption does not result in weight gain and results in small reductions in LDL cholesterol and diastolic blood pressure, as well as improved glycemic responses in certain populations (i.e. Asian Indians). A number of research gaps on almond consumption and cardiometabolic health were identified that should be addressed to further understand their role in the various cardiometabolic endpoints, including the mechanisms of action interactions with the microbiome with regular consumption and their role as part of a healthy dietary pattern for both individuals and the general population.

摘要

全世界的人都食用杏仁。由于杏仁富含蛋白质、不饱和脂肪酸和纤维,因此针对其在影响各种心血管代谢指标(体重、血压、血液胆固醇水平和血糖反应)方面的作用开展了大量研究。关于食用杏仁与各种健康相关指标的最新荟萃分析表明,食用杏仁不会导致体重增加,还会使低密度脂蛋白胆固醇和舒张压略有降低,并且在某些人群(如亚洲印度人)中能改善血糖反应。研究发现了一些关于食用杏仁与心血管代谢健康方面的研究空白,需要加以解决,以便进一步了解杏仁在各种心血管代谢指标中的作用,包括经常食用时与微生物群的作用机制相互作用,以及它们作为个人和普通人群健康饮食模式一部分的作用。