Department of Internal Medicine, "S. Maria Delle Grazie", Pozzuoli Hospital, Naples, Italy.
Department of Translational Medical Science, Section of Pediatrics, Regional Center for Pediatric Diabetes, University of Naples Federico II, Via S. Pansini 5, 80131, Naples, Italy.
Sci Rep. 2022 Jul 15;12(1):12153. doi: 10.1038/s41598-022-15484-0.
The aim of this study was to investigate the association between uric acid (UA) and cardiometabolic risk factors (CMRFs) by sex in youth with type 1 diabetes (T1D). Retrospective data collected from 1323 children and adolescents (5-18 years; 716 boys) with T1D recruited in 9 Italian Pediatric Diabetes Centers were analyzed. CMRFs included UA, HbA, blood pressure (BP), cholesterol (TC), HDL, triglycerides (TG), neutrophils (N) and lymphocytes (L) count, glomerular filtration rate (eGFR) (calculated using Schwartz-Lyon equation). In boys, we found a higher age, daily insulin dose, TG, TG/HDL ratio, TC/HDL ratio, systolic BP, N/L ratio and lower HDL, and eGFR across UA tertiles (p = 0.01-0.0001). Similar results were found in girls but not for TG and systolic BP. In boys, the odds ratio (OR) of high levels of TG/HDL ratio, TC/HDL ratio, BP and mildly reduced eGFR (MRGFR) increased for 0.5 mg/dL of UA. Instead, in girls an increased levels of 0.5 mg/dL of UA were associated with high OR of TC/HDL ratio, N/L ratio and MRGFR. Uric acid may represent a useful marker for identifying youth with T1D at high cardiometabolic risk, and this association appears to vary by sex.
本研究旨在探讨血尿酸（UA）与 1 型糖尿病（T1D）青少年性别相关的代谢危险因素（CMRFs）之间的关系。对 9 个意大利儿科糖尿病中心招募的 1323 名青少年（5-18 岁；716 名男性）的回顾性数据进行了分析。CMRFs 包括 UA、HbA、血压（BP）、胆固醇（TC）、高密度脂蛋白（HDL）、甘油三酯（TG）、中性粒细胞（N）和淋巴细胞（L）计数、肾小球滤过率（eGFR）（使用 Schwartz-Lyon 方程计算）。在男性中，我们发现随着 UA 三分位数的升高，年龄、每日胰岛素剂量、TG、TG/HDL 比值、TC/HDL 比值、收缩压、N/L 比值升高，HDL 降低，eGFR 降低（p 值为 0.01-0.0001）。在女性中也发现了类似的结果，但 TG 和收缩压除外。在男性中，TG/HDL 比值、TC/HDL 比值、BP 和轻度降低的 eGFR（MRGFR）的高水平与 UA 增加 0.5mg/dL 的比值的比值比（OR）增加。然而，在女性中，UA 增加 0.5mg/dL 与 TC/HDL 比值、N/L 比值和 MRGFR 的高 OR 相关。UA 可能是一种有用的标志物，可用于识别 T1D 青少年中处于高心血管代谢风险的人群，这种关联似乎因性别而异。
