Ghiringhelli Gaia, Borelli Francesco, Vaienti Luca
Plastic and Reconstructive Surgery, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Galeazzi-Sant'Ambrogio, Milan, ITA.
Cureus. 2025 Jan 2;17(1):e76795. doi: 10.7759/cureus.76795. eCollection 2025 Jan.
This case report describes a rare case of an endocrine mucin-producing carcinoma (EMPC) in an 84-year-old male patient presenting with a cutaneous lesion in the left infraorbital region. EMPC is a rare cutaneous neoplasm characterized by the presence of basaloid cells that produce mucin, alongside features of neuroendocrine differentiation. It often poses diagnostic challenges due to its histological overlap with other skin tumors, such as basal cell carcinoma and mucinous carcinoma. The patient underwent outpatient surgery for the excision of the lesion and reconstruction with a Mustardé-like local flap. Histological examination revealed an ulcerated neoplasm composed of mucin-secreting basaloid cells with focal neuroendocrine differentiation. This case is discussed in the context of the existing literature on EMPC.
本病例报告描述了一例罕见的内分泌黏液产生性癌（EMPC），患者为一名84岁男性，其左眶下区域出现皮肤病变。EMPC是一种罕见的皮肤肿瘤，其特征是存在产生黏液的基底样细胞以及神经内分泌分化特征。由于其组织学表现与其他皮肤肿瘤（如基底细胞癌和黏液癌）重叠，它常常带来诊断挑战。患者接受了门诊手术，切除病变并用类似Mustardé的局部皮瓣进行重建。组织学检查显示为一个溃疡型肿瘤，由分泌黏液的基底样细胞组成，并伴有局灶性神经内分泌分化。本文结合关于EMPC的现有文献对该病例进行了讨论。
