Sun Yuehua, Liu Yingchun, Li Chuntao, Zhang Xiaodong, Yin Lu, Niu Jun
Department of Dermatology, General Hospital of Northern Theater Command, Shenyang, China.
Front Oncol. 2024 Nov 18;14:1449270. doi: 10.3389/fonc.2024.1449270. eCollection 2024.
Endocrine mucin-producing sweat gland carcinoma is a rare neoplasm of the skin appendages. The tumor typically exhibits slow growth and rarely metastasizes to distant sites. Herein, we report a case of a 77-year-old male who presented with a skin lesion on the right anterior chest wall 23 years ago. Fifteen years later, surgical excision was performed, and the pathological diagnosis was endocrine mucin-producing sweat gland carcinomas. However, the histopathological examination revealed a coexistence of endocrine mucin-producing sweat gland carcinomas and mucinous carcinoma components. Over the past 2 years, the patient developed lymph node metastasis in the right axilla, local recurrence on the right chest wall, and distant skin metastasis. The histopathological type of the lymph node metastasis was consistent with the primary tumor, while the recurrent and skin metastatic lesions exhibited mucinous carcinoma. To our knowledge, this is the first reported case of endocrine mucin-producing sweat gland carcinoma with distant skin metastasis, characterized by two distinct carcinoma components in the histopathological morphology.
内分泌黏液生成性汗腺癌是一种罕见的皮肤附属器肿瘤。该肿瘤通常生长缓慢，很少转移至远处部位。在此，我们报告一例77岁男性患者，23年前其右前胸壁出现皮肤病变。15年后进行了手术切除，病理诊断为内分泌黏液生成性汗腺癌。然而，组织病理学检查显示内分泌黏液生成性汗腺癌与黏液腺癌成分并存。在过去2年中，患者出现右腋窝淋巴结转移、右胸壁局部复发及远处皮肤转移。淋巴结转移的组织病理学类型与原发肿瘤一致，而复发及皮肤转移病变表现为黏液腺癌。据我们所知，这是首例报道的伴有远处皮肤转移的内分泌黏液生成性汗腺癌病例，其组织病理学形态具有两种不同的癌成分。
