Irie T, Sakai H, Mae S
Jpn J Antibiot. 1985 Jan;38(1):74-82.
Cefoxitin (CFX) was administrated to a total of 12 hospitalized patients with digestive diseases, in combination with aminoglycosides. The following results were obtained: Clinical effects of CFX on 12 cases were "excellent" in 4 cases, "good" in 5, "fair" in 1 and "unknown" in 2, with the efficacy rate of 75%. All 4 cases who developed septicemia with underlying severe diseases showed "excellent" effect to CFX. Clinical results of 8 cases with hepatic biliary tract infections were "good" in 5, "fair" in 1 and "unknown" in 2, with the efficacy rate in 62.5%. As for side effects, an allergic reaction was observed in 1 case, and it is suggested renal function should be monitored carefully in a case of combination use with aminoglycosides.
将头孢西丁(CFX)与氨基糖苷类药物联合应用于12例住院消化系统疾病患者。结果如下:CFX对12例患者的临床疗效为:4例“优”,5例“良”,1例“中”,2例“未知”,有效率为75%。所有4例患有严重基础疾病并发败血症的患者对CFX均显示“优”效。8例肝胆道感染患者的临床结果为:5例“良”,1例“中”,2例“未知”,有效率为62.5%。至于副作用,观察到1例过敏反应,建议在与氨基糖苷类药物联合使用时应仔细监测肾功能。