Sausukpaiboon Karnchanit, Penboon Nuanpan, Rianthavorn Pornpimol
Division of Nephrology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Clin Exp Pediatr. 2025 Jun;68(6):454-462. doi: 10.3345/cep.2024.01340. Epub 2025 Feb 3.
Coronavirus disease 2019 (COVID-19) vaccination remains an essential strategy for reducing disease burden. Specific guidelines for vaccinating children with systemic lupus erythematosus (SLE) are currently unavailable, highlighting the gap in tailored recommendations for this population.
This study aimed to estimate parental intention to vaccinate children with SLE against COVID-19 and identify factors associated with this intention. It also explored parents' attitudes toward the vaccine.
Seventy-four parents of patients aged 5-21 years who were diagnosed with SLE before 18 years of age were surveyed regarding their willingness to further vaccinate their children with SLE against COVID-19. The parents were categorized into vaccine acceptance (VA) and vaccine hesitancy (VH) groups and completed a validated 6-item questionnaire designed to gauge their attitudes toward the vaccine. Vaccine hesitancy scale (VHS) scores were calculated with higher scores indicating increased VH. The adjusted odds ratios (aOR) (95% confidence interval [CI]) for VA-associated factors were determined using multivariate analysis.
Twenty-five parents (33.8%) were diagnosed with VH. Compared with the VH group, the VA group showed a higher frequency of previous COVID-19 vaccine uptake, completed immunization in children, and parental willingness to be vaccinated themselves. Children were older in the VA versus VH group. The mean total VHS score was significantly higher in the VH versus VA group. In a multivariate model of factors differing significantly between the VA and VH groups, parental willingness to vaccinate themselves (aOR, 5.0; 95% CI, 1.2-20.4), patient age (aOR, 1.4; 95% CI, 1.1-1.9), and VHS score on vaccine efficacy belief (aOR, 0.1 [0.0-0.5]) were significantly associated with VA.
A significant proportion of parents were hesitant to vaccinate their children with SLE against COVID-19. These insights underscore the importance of developing targeted educational interventions to address specific parental concerns and improve vaccine uptake in children with SLE.
2019年冠状病毒病（COVID-19）疫苗接种仍然是减轻疾病负担的重要策略。目前尚无针对系统性红斑狼疮（SLE）儿童接种疫苗的具体指南，这凸显了针对该人群的定制化建议方面的差距。
本研究旨在评估父母为患有SLE的儿童接种COVID-19疫苗的意愿，并确定与该意愿相关的因素。研究还探讨了父母对疫苗的态度。
对74名5至21岁、18岁之前被诊断为SLE的患者的父母进行了调查，询问他们是否愿意为患有SLE的孩子进一步接种COVID-19疫苗。将父母分为疫苗接受（VA）组和疫苗犹豫（VH）组，并完成一份经过验证的6项问卷，以衡量他们对疫苗的态度。计算疫苗犹豫量表（VHS）得分，得分越高表明疫苗犹豫程度越高。使用多变量分析确定与VA相关因素的调整比值比（aOR）（95%置信区间[CI]）。
25名父母（33.8%）被诊断为疫苗犹豫。与疫苗犹豫组相比，疫苗接受组之前接种COVID-19疫苗的频率更高、孩子完成免疫接种的比例更高，且父母自身愿意接种疫苗的比例更高。疫苗接受组的孩子年龄比疫苗犹豫组大。疫苗犹豫组的VHS总平均分显著高于疫苗接受组。在疫苗接受组和疫苗犹豫组之间存在显著差异的因素的多变量模型中，父母自身接种疫苗的意愿（aOR，5.0；95%CI，1.2-20.4）、患者年龄（aOR，1.4；95%CI，1.1-1.9）以及对疫苗效力信念的VHS得分（aOR，0.1[0.0-0.5]）与疫苗接受显著相关。
相当一部分父母对为患有SLE的孩子接种COVID-19疫苗持犹豫态度。这些见解强调了制定有针对性的教育干预措施以解决父母的具体担忧并提高SLE儿童疫苗接种率的重要性。
