力量训练对帕金森病患者身体功能表现的影响：一项随机对照试验的系统评价与荟萃分析

Effect of power training on physical functional performance of patients with Parkinson's disease: A systematic review and meta-analysis of randomized controlled trials.

作者信息

de Almeida Samuel Brito, Tavares Sobreira Emmanuelle Silva, de Lucena Alves Charles Phillipe, Lima Danielle Pessoa, de Carvalho Bonfadini Janine, Sobreira-Neto Manoel Alves, Freitas Thiago Holanda, do Nascimento Simony Lira, Braga-Neto Pedro

机构信息

Clinical Research Unit, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, Ceara, Brazil.

Graduate Program in Epidemiology, University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.

出版信息

PLoS One. 2025 Feb 4;20(2):e0314058. doi: 10.1371/journal.pone.0314058. eCollection 2025.

INTRODUCTION

Parkinson's disease (PD) is becoming more prevalent, highlighting the urgency of developing treatments to minimize its effects on muscular strength and physical function. Power training (PT) is a potential approach that may improve endurance and muscular power, essential for maintaining functional ability in PD.

OBJECTIVE

To compare the effect of PT versus control or other physical activity (PA) interventions on physical functional performance (PFP) in PD patients.

METHODS

We searched PubMed, MEDLINE, Embase, LILACS, PEDro, Cochrane Library, and Scopus. Inclusion criteria were randomized controlled trials comparing PT to a control group or another PA intervention in PD patients. PFP was the primary outcome. Pooled effect estimates were calculated from baseline to endpoint scores.

RESULTS

From 21,558 results, four studies were included in the meta-analysis due to their moderate to high methodological quality. PT showed no significant effect on PFP outcomes compared to control groups (TUG: ES, -0.281; 95% CI, -0.693 to 0.130; P = 0.180; I2:0%; PWS: ES, 0.748; 95% CI, -0.768 to 2.265; P = 0.333; I2:88%; FWS: ES, 0.420; 95% CI, -0.950 to 1.791; P = 0.548; I2:83%; SLS: ES, 0.161; 95% CI, -0.332 to 0.655; P = 0.521; I2:0%). No differences were found between PT and alternative interventions (TUG: ES, 0.132; 95% CI, -0.394 to 0.657; P = 0.623; I2:0%; BBA: ES, 0.057; 95% CI, -0.430 to 0.544; P = 0.820; I2:0%).

CONCLUSION

PT did not improve PFP compared to control or alternative interventions. More studies are needed to explore PT effects (e.g., higher volume, intensity, and combined types) in PD patients.

引言

帕金森病（PD）正变得越来越普遍，这凸显了开发治疗方法以尽量减少其对肌肉力量和身体功能影响的紧迫性。力量训练（PT）是一种潜在的方法，可能会改善耐力和肌肉力量，这对于维持帕金森病患者的功能能力至关重要。

目的

比较力量训练与对照或其他体育活动（PA）干预措施对帕金森病患者身体功能表现（PFP）的影响。

方法

我们检索了PubMed、MEDLINE、Embase、LILACS、PEDro、Cochrane图书馆和Scopus。纳入标准为比较帕金森病患者力量训练与对照组或其他体育活动干预措施的随机对照试验。身体功能表现是主要结局。计算从基线到终点得分的合并效应估计值。

结果

在21558条结果中，由于方法学质量为中到高，四项研究被纳入荟萃分析。与对照组相比，力量训练对身体功能表现结局无显著影响（定时起立行走测试：效应量，-0.281；95%置信区间，-0.693至0.130；P = 0.180；I²：0%；峰值功率输出：效应量，0.748；95%置信区间，-0.768至2.265；P = 0.333；I²：88%；功能性步行速度：效应量，0.420；95%置信区间，-0.950至1.791；P = 0.548；I²：83%；简短体能状况量表：效应量，0.161；95%置信区间，-0.332至0.655；P = 0.521；I²：0%）。力量训练与替代干预措施之间未发现差异（定时起立行走测试：效应量，0.132；95%置信区间，-0.394至0.657；P = 0.623；I²：0%；伯格平衡量表：效应量，0.057；95%置信区间，-0.430至0.544；P = 0.820；I²：0%）。