Rodriguez-Lopez Carlos, Alcazar Julian, Losa-Reyna Jose, Martin-Espinosa Noelia Maria, Baltasar-Fernandez Ivan, Ara Ignacio, Csapo Robert, Alegre Luis M
GENUD Toledo Research Group, Universidad de Castilla-La Mancha, Toledo, Spain.
CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.
Front Physiol. 2021 Feb 18;12:635094. doi: 10.3389/fphys.2021.635094. eCollection 2021.
Power-oriented resistance training (PRT) is one of the most effective exercise programs to counteract neuromuscular and physical function age-related declines. However, the optimal load that maximizes these outcomes or the load-specific adaptations induced on muscle power determinants remain to be better understood. Furthermore, to investigate whether these adaptations are potentially transferred to an untrained limb (i.e., cross-education phenomenon) could be especially relevant during limb-immobilization frequently observed in older people (e.g., after hip fracture).
At least 30 well-functioning older participants (>65 years) will participate in a within-person randomized controlled trial. After an 8-week control period, the effects of two 12-week PRT programs using light vs. heavy loads will be compared using an unilateral exercise model through three study arms (light-load PRT vs. non-exercise; heavy-load PRT vs. non-exercise; and light- vs. heavy- load PRT). Muscle-tendon function, muscle excitation and morphology and physical function will be evaluated to analyze the load-specific effects of PRT in older people. Additionally, the effects of PRT will be examined on a non-exercised contralateral limb.
Tailored exercise programs are largely demanded given their potentially greater efficiency preventing age-related negative consequences, especially during limb-immobilization. This trial will provide evidence supporting the use of light- or heavy-load PRT on older adults depending on individual needs, improving decision making and exercise program efficacy.
NCT03724461 registration data: October 30, 2018.
以力量为导向的抗阻训练（PRT）是对抗神经肌肉和身体功能与年龄相关衰退的最有效运动项目之一。然而，能使这些效果最大化的最佳负荷，或对肌肉力量决定因素产生的特定负荷适应性变化，仍有待进一步了解。此外，研究这些适应性变化是否能潜在地转移到未训练的肢体上（即交叉训练现象），在老年人中常见的肢体固定情况下（如髋部骨折后）可能尤为重要。
至少30名功能良好的老年参与者（>65岁）将参与一项自身随机对照试验。在为期8周的对照期后，将通过三个研究组，采用单侧运动模型比较两个为期12周的PRT项目（轻负荷与重负荷）的效果（轻负荷PRT组与非运动组；重负荷PRT组与非运动组；轻负荷与重负荷PRT组）。将评估肌肉肌腱功能、肌肉兴奋性和形态以及身体功能，以分析PRT对老年人的特定负荷效应。此外，还将研究PRT对未运动的对侧肢体的影响。
鉴于定制的运动项目在预防与年龄相关的负面后果方面可能具有更高的效率，尤其是在肢体固定期间，因此对其有很大需求。该试验将提供证据，支持根据个体需求对老年人使用轻负荷或重负荷PRT，改善决策制定和运动项目效果。
NCT03724461 注册数据：2018年10月30日。
