衰老细胞溶解化合物可在体外降低血液样本的表观遗传年龄。

Tharmapalan Vithurithra, Du Marchie Sarvaas Miriam, Bleichert Michael, Wessiepe Martina, Wagner Wolfgang

Institute for Stem Cell Biology, RWTH Aachen University Medical School, 52074, Aachen, Germany.

Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Medical Faculty, 52074, Aachen, Germany.

NPJ Aging. 2025 Feb 4;11(1):6. doi: 10.1038/s41514-025-00199-z.

Senolytic drugs raise the expectation that they can specifically eliminate a subset of senescent cells in a given tissue. In this study, we have exemplarily analyzed if a 3-day treatment of human blood samples in vitro would reduce age-associated biomarkers, with a particular focus on epigenetic age-predictions. Of eight tested compounds, JQ1, RG7112, nutlin-3a, and AMG232 reduced epigenetic age, indicating that this approach may be useful in drug screening for senolytic compounds.

衰老细胞裂解药物让人期待它们能够特异性地清除特定组织中的衰老细胞亚群。在本研究中，我们已进行了示例性分析，即体外对人类血液样本进行为期3天的处理是否会降低与年龄相关的生物标志物，特别关注表观遗传年龄预测。在八种测试化合物中，JQ1、RG7112、nutlin-3a和AMG232降低了表观遗传年龄，表明这种方法可能有助于衰老细胞裂解化合物的药物筛选。