Santiago Raí Dos Santos, Araújo Jaya Miranda Carvalho de, Nascimento Márcia Helena Cassago, Anhoque Carolina Fiorin, Neves Alana Tagarro, Depolli Gabriel Trevizani, Castrillo Bruno Batitucci, Dias Paula Zago Melo, Vanzo Regina Eliza Albano, Nascimento Carla Carvalho, Barauna Valerio Garrone, Rodrigues Lívia Carla de Melo
Universidade Federal do Espírito Santo - UFES - Vitória (ES), Brasil.
Universidade Federal de São Paulo - UNIFESP - São Paulo (SP), Brasil.
Codas. 2025 Feb 3;37(1):e20230320. doi: 10.1590/2317-1782/e20230320pt. eCollection 2025.
to describe sociodemographic characteristics of individuals with multiple sclerosis and correlate and compare vocal fatigue, voice handicap, and voice-related quality of life of individuals with and without the disease.
Cross-sectional, quantitative study with 52 volunteers with multiple sclerosis and 52 control volunteers, matched by sex, age, and education level. Sociodemographic and clinical data were collected through a questionnaire and medical record analysis. Participants responded to the reduced Voice Handicap Index (VHI-10), Vocal Fatigue Index (VFI), and Voice-Related Quality of Life (V-RQOL). Correlational and comparative analyses were performed, with a 5% significance level (p < 0.05).
There was a greater predominance of females diagnosed with multiple sclerosis, with a mean age of 40 years, who graduated from high school, and with a relapsing-remitting disease course. Voice handicap was positively correlated with vocal fatigue, and voice handicap and vocal fatigue were negatively correlated with voice-related quality of life in both groups. Participants with multiple sclerosis exceeded the VHI-10 and VFI cutoff scores and were below the V-RQOL cutoff score.
There was a prevalence of the disease in young, educated females with relapsing-remitting disease. The greater the voice handicap and/or vocal fatigue, the lower the voice-related quality of life in both groups. However, people with multiple sclerosis self-reported greater voice handicap and vocal fatigue and poorer voice-related quality of life.
描述多发性硬化症患者的社会人口学特征，并对患病人群和未患病人群的嗓音疲劳、嗓音障碍及嗓音相关生活质量进行相关性分析和比较。
采用横断面定量研究，招募52名多发性硬化症志愿者和52名对照志愿者，两组在性别、年龄和教育水平上相匹配。通过问卷调查和病历分析收集社会人口学和临床数据。参与者回答简化版嗓音障碍指数（VHI-10）、嗓音疲劳指数（VFI）和嗓音相关生活质量（V-RQOL）问卷。进行相关性和比较性分析，显著性水平为5%（p < 0.05）。
被诊断为多发性硬化症的女性占比更大，平均年龄为40岁，高中毕业，疾病类型为复发缓解型。两组中，嗓音障碍与嗓音疲劳呈正相关，嗓音障碍和嗓音疲劳与嗓音相关生活质量呈负相关。多发性硬化症患者的VHI-10和VFI得分超过临界值，V-RQOL得分低于临界值。
该疾病在患有复发缓解型疾病、受过教育的年轻女性中更为普遍。两组中，嗓音障碍和/或嗓音疲劳越严重，嗓音相关生活质量越低。然而，多发性硬化症患者自我报告的嗓音障碍和嗓音疲劳更严重，嗓音相关生活质量更差。
