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[单独或与乙醇联合应用的两种有机汞化合物在小鼠出生前或出生后应用后的比较研究]

[Comparative studies of 2 organic mercury compounds alone or in combination with ethanol following pre- or postnatal application in mice].

作者信息

Bleyl D W, Klein S, Woggon H

出版信息

Nahrung. 1985;29(1):93-103. doi: 10.1002/food.19850290124.

DOI:10.1002/food.19850290124
PMID:3990780
Abstract

Studies on pre- and/or postnatal effects on mice were carried out with their identical exposure (2 mg Hg/kg body mass) to phenyl mercuric acetate or N,N'-bis-(dimethylmercury)-p-toluol-sulphonamide. Parameters of morphology, of residues, and behaviour teratology were taken into consideration. Potentiating combination effects were only observed with behaviour toxicological investigations after prenatal exposure to methylmercury. That concerned the breeding results of the P-generation and the capacity of the F1-generation to learn on the 30th and 31st day p.n. during a swimming test in a labyrinth. Synergistic effects were observed with both the mercury compounds in the swimming test on the 12th day p.n. after pre- as well as postnatal exposure.

摘要

对小鼠进行了关于产前和/或产后影响的研究,使其以相同剂量(2毫克汞/千克体重)接触醋酸苯汞或N,N'-双(二甲基汞)-对甲苯磺酰胺。考虑了形态学、残留参数和行为毒理学参数。仅在产前接触甲基汞后的行为毒理学研究中观察到增强的联合效应。这涉及P代的繁殖结果以及F1代在出生后第30天和第31天在迷宫游泳试验中的学习能力。在产前和产后接触后的出生后第12天的游泳试验中,两种汞化合物都观察到了协同效应。

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1
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Nahrung. 1985;29(1):93-103. doi: 10.1002/food.19850290124.
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