Yang Chenbo, Li Yiwei, Chen Chao, Sun Zexin, Liu Enjie, Wei Na, Liu Xiaonan, Shu Jiao, Zhao Na, Sun Miaomiao
Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
Henan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, People's Republic of China.
Mol Neurobiol. 2025 Jun;62(6):7525-7541. doi: 10.1007/s12035-025-04729-4. Epub 2025 Feb 5.
Long non-coding RNAs (LncRNAs) have emerged as pivotal regulators in the pathogenesis of Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. With the capacity to modulate gene expression at various levels, LncRNAs are implicated in multiple pathological mechanisms of AD, including amyloid-beta (Aβ) accumulation, tau protein phosphorylation, neuroinflammation, and neuronal apoptosis. Recent studies have highlighted the potential of LncRNAs as diagnostic biomarkers and therapeutic targets due to their differential expression patterns in AD patients. This review synthesizes current knowledge on the role of LncRNAs in AD, focusing on their involvement in key molecular pathways and their promise as indicators for early diagnosis and prognosis. We discuss the regulatory networks of LncRNAs in the context of AD, their interaction with miRNAs, and the implications for developing novel therapeutic strategies. Despite the complexity and variability in LncRNA function, the prospect of harnessing these molecules for precision medicine in AD is gaining momentum. The translational potential of LncRNA-based interventions offers a new frontier in the quest for effective treatments and a deeper understanding of the molecular underpinnings of AD.
长链非编码RNA（LncRNAs）已成为阿尔茨海默病（AD）发病机制中的关键调节因子，AD是一种以认知衰退和记忆丧失为特征的进行性神经退行性疾病。LncRNAs具有在多个水平调节基因表达的能力，参与AD的多种病理机制，包括β淀粉样蛋白（Aβ）积累、tau蛋白磷酸化、神经炎症和神经元凋亡。最近的研究强调了LncRNAs作为诊断生物标志物和治疗靶点的潜力，因为它们在AD患者中具有差异表达模式。这篇综述综合了关于LncRNAs在AD中作用的当前知识，重点关注它们在关键分子途径中的参与情况以及作为早期诊断和预后指标的前景。我们讨论了AD背景下LncRNAs的调控网络、它们与微小RNA（miRNAs）的相互作用以及对开发新型治疗策略的意义。尽管LncRNA功能复杂且多变，但利用这些分子进行AD精准医学的前景正日益受到关注。基于LncRNA的干预措施的转化潜力为寻求有效治疗方法和更深入了解AD的分子基础开辟了新的前沿领域。
