Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Medical Research Group of Egypt, Cairo, Egypt.
CNS Neurol Disord Drug Targets. 2024;23(6):731-745. doi: 10.2174/1871527322666230519113201.
Long non-coding RNAs (IncRNAs) are regulatory RNA transcripts that have recently been associated with the onset of many neurodegenerative illnesses, including Alzheimer's disease (AD). Several IncRNAs have been found to be associated with AD pathophysiology, each with a distinct mechanism. In this review, we focused on the role of IncRNAs in the pathogenesis of AD and their potential as novel biomarkers and therapeutic targets. Searching for relevant articles was done using the PubMed and Cochrane library databases. Studies had to be published in full text in English in order to be considered. Some IncRNAs were found to be upregulated, while others were downregulated. Dysregulation of IncRNAs expression may contribute to AD pathogenesis. Their effects manifest as the synthesis of beta-amyloid (Aβ) plaques increases, thereby altering neuronal plasticity, inducing inflammation, and promoting apoptosis. Despite the need for more investigations, IncRNAs could potentially increase the sensitivity of early detection of AD. Until now, there has been no effective treatment for AD. Hence, InRNAs are promising molecules and may serve as potential therapeutic targets. Although several dysregulated AD-associated lncRNAs have been discovered, the functional characterization of most lncRNAs is still lacking.
长链非编码 RNA（IncRNA）是一种新发现的与多种神经退行性疾病（包括阿尔茨海默病，AD）的发生相关的调节性 RNA 转录物。有几种 IncRNA 被发现与 AD 病理生理学有关，每种 IncRNA 都有其独特的机制。在本综述中，我们重点关注 IncRNA 在 AD 发病机制中的作用及其作为新型生物标志物和治疗靶点的潜力。使用 PubMed 和 Cochrane 图书馆数据库搜索相关文章。为了被考虑，研究必须以英文全文发表。一些 IncRNA 被发现上调，而另一些则下调。IncRNA 表达失调可能导致 AD 发病机制。它们的影响表现为β-淀粉样蛋白（Aβ）斑块的合成增加，从而改变神经元可塑性，诱导炎症，促进细胞凋亡。尽管需要更多的研究，但 IncRNA 可能会提高 AD 早期检测的敏感性。到目前为止，AD 还没有有效的治疗方法。因此，IncRNA 是很有前途的分子，可能作为潜在的治疗靶点。尽管已经发现了几种与 AD 相关的失调 IncRNA，但大多数 IncRNA 的功能特征仍不清楚。
