Hwang Hyunchan, Kim Sun Mi, Kim Hee Jin, Han Doug Hyun
Department of Psychiatry, College of Medicine, Chung Ang University, Seoul, South Korea.
Department of Psychiatry, College of Medicine, Chung Ang University, Seoul, South Korea.
Psychiatry Res. 2025 Mar;345:116376. doi: 10.1016/j.psychres.2025.116376. Epub 2025 Jan 26.
Schizophrenia and attention deficit hyperactivity disorder (ADHD) have many contradicting features, but both these disorders share inattention as a core symptom. This study explored how the characteristics of inattention differ between the two disorders. 20 patients with schizophrenia, 20 patients with adult ADHD and 20 healthy controls participated in this study. Comprehensive attention test, Korean Wechsler adult intelligence scale-IV and resting-state functional magnetic resonance imaging (fMRI) were collected, among other things. The schizophrenia and ADHD groups showed low and high levels of functional connectivity in the default mode network (DMN), respectively. Functional connectivity level within the DMN was also positively correlated with processing speed index in the schizophrenia group and positively correlated with the number of divided-attention commission errors in the ADHD group. These results show that schizophrenia and adult ADHD have similarities in the characteristics of attention deficit, in that both may arise from dysregulation within the DMN. However, the differences in the levels of functional connectivity in the DMN between these groups affect how inattention manifests in each group.
精神分裂症和注意力缺陷多动障碍（ADHD）有许多相互矛盾的特征，但这两种疾病都将注意力不集中作为核心症状。本研究探讨了这两种疾病中注意力不集中的特征有何不同。20名精神分裂症患者、20名成人ADHD患者和20名健康对照者参与了本研究。除其他外，还收集了综合注意力测试、韩国韦氏成人智力量表第四版和静息态功能磁共振成像（fMRI）。精神分裂症组和ADHD组在默认模式网络（DMN）中的功能连接水平分别较低和较高。DMN内的功能连接水平在精神分裂症组中也与处理速度指数呈正相关，在ADHD组中与分心任务中的错误数呈正相关。这些结果表明，精神分裂症和成人ADHD在注意力缺陷特征方面有相似之处，因为两者都可能源于DMN内的调节异常。然而，这些组之间DMN中功能连接水平的差异影响了每组中注意力不集中的表现方式。
