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整合心电图和眼底图像用于心血管疾病的早期检测。

Integrating electrocardiogram and fundus images for early detection of cardiovascular diseases.

作者信息

Muthukumar K A, Nandi Dhruva, Ranjan Priya, Ramachandran Krithika, Pj Shiny, Ghosh Anirban, M Ashwini, Radhakrishnan Aiswaryah, Dhandapani V E, Janardhanan Rajiv

机构信息

University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India.

Faculty of Medicine and Health Sciences , SRM Medical College Hospital and Research Centre, SRM IST, Kattankulathur, Chengalpattu, Tamil Nadu, India.

出版信息

Sci Rep. 2025 Feb 5;15(1):4390. doi: 10.1038/s41598-025-87634-z.

Abstract

Cardiovascular diseases (CVD) are a predominant health concern globally, emphasizing the need for advanced diagnostic techniques. In our research, we present an avant-garde methodology that synergistically integrates ECG readings and retinal fundus images to facilitate the early disease tagging as well as triaging of the CVDs in the order of disease priority. Recognizing the intricate vascular network of the retina as a reflection of the cardiovascular system, alongwith the dynamic cardiac insights from ECG, we sought to provide a holistic diagnostic perspective. Initially, a Fast Fourier Transform (FFT) was applied to both the ECG and fundus images, transforming the data into the frequency domain. Subsequently, the Earth Mover's Distance (EMD) was computed for the frequency-domain features of both modalities. These EMD values were then concatenated, forming a comprehensive feature set that was fed into a Neural Network classifier. This approach, leveraging the FFT's spectral insights and EMD's capability to capture nuanced data differences, offers a robust representation for CVD classification. Preliminary tests yielded a commendable accuracy of 84%, underscoring the potential of this combined diagnostic strategy. As we continue our research, we anticipate refining and validating the model further to enhance its clinical applicability in resource limited healthcare ecosystems prevalent across the Indian sub-continent and also the world at large.

摘要

心血管疾病(CVD)是全球主要的健康问题,这凸显了对先进诊断技术的需求。在我们的研究中,我们提出了一种前卫的方法,该方法将心电图读数和视网膜眼底图像协同整合,以便对心血管疾病进行早期疾病标记,并按照疾病优先级对其进行分类。认识到视网膜复杂的血管网络是心血管系统的反映,以及心电图提供的动态心脏信息,我们试图提供一个全面的诊断视角。最初,对心电图和眼底图像都应用了快速傅里叶变换(FFT),将数据转换到频域。随后,计算两种模态频域特征的推土机距离(EMD)。然后将这些EMD值连接起来,形成一个综合特征集,输入到神经网络分类器中。这种方法利用FFT的频谱洞察力和EMD捕捉细微数据差异的能力,为心血管疾病分类提供了强大的表示。初步测试取得了84%的可观准确率,突出了这种联合诊断策略的潜力。随着我们继续开展研究,我们期望进一步完善和验证该模型,以增强其在印度次大陆及全球普遍存在的资源有限的医疗生态系统中的临床适用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a7a/11799439/b18a7c72eb58/41598_2025_87634_Fig1_HTML.jpg

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