Fan Yong, Feigenberg Steven J, Simone Charles B
Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3700 Hamilton Walk, Philadelphia, PA 19104-6116, USA.
Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, 2 West, Philadelphia, PA 19104, USA.
PET Clin. 2025 Apr;20(2):185-193. doi: 10.1016/j.cpet.2025.01.002. Epub 2025 Feb 5.
This review delves into the principles of PET imaging and radiomics, emphasizing their importance in detecting, staging, and monitoring various cancers. It highlights the clinical applications of PET radiomics in oncology, showcasing its impact on personalized cancer care. Additionally, the review addresses challenges such as standardizing PET radiomics, integrating multiomics data, and ethical concerns in clinical decision-making. Future directions are also discussed, including broader applications of PET radiomics in clinical trials, artificial intelligence integration for automated analysis, and incorporating multiomics data for a comprehensive understanding of tumor biology.
本综述深入探讨了正电子发射断层扫描(PET)成像和放射组学的原理,强调了它们在检测、分期和监测各种癌症中的重要性。它突出了PET放射组学在肿瘤学中的临床应用,展示了其对个性化癌症治疗的影响。此外,该综述还讨论了一些挑战,如PET放射组学的标准化、多组学数据的整合以及临床决策中的伦理问题。还讨论了未来的发展方向,包括PET放射组学在临床试验中的更广泛应用、用于自动分析的人工智能整合,以及纳入多组学数据以全面了解肿瘤生物学。