Nunn Martha E, Rudick Courtney, Nikaido Masahiko, Miyamoto Takanari
Nunn Biostatistical Solutions, Omaha, NE, United States.
Private Practitioner, Omaha, NE, United States.
Front Dent Med. 2024 Aug 16;5:1418039. doi: 10.3389/fdmed.2024.1418039. eCollection 2024.
The objectives of this study are to provide a systematic review of a novel alloplastic hard-tissue grafting material, carbonate apatite granules (CO3Ap-granules), to provide a clinical case presentation of CO3Ap-granules in periodontal surgery. The following three electronic databases were searched independently by two of the authors (MN) and (CR): National Library of Medicine [MEDLINE (PubMed) and ClinicalTrials.gov], EMBASE (OVID) and the Cochrane Central Register of Controlled Trials (CENTRAL). After searching electronic databases, select journals in periodontics and implantology were also manually searched. Of the 43 studies identified from the systematic review, the following classifications were determined: (1) studies - 5 studies, (2) animal studies - 28 studies, (3) clinical studies - 7 studies, (4) reviews - 3 studies. Results from selected animal studies and all human studies were summarized. These results demonstrate that the novel alloplast CO3Ap-granules has the potential ability to stimulate new bone formation while CO3Ap-granules simultaneously resorb over time. Replacement of CO3Ap-granules with new bone formation has been shown to be comparable to autogenous bone grafting with one study showing superior results to a bovine-derived xenograft.
本研究的目的是对一种新型异体硬组织移植材料——碳酸磷灰石颗粒（CO3Ap颗粒）进行系统综述，并提供CO3Ap颗粒在牙周手术中的临床病例展示。由两位作者（MN）和（CR）独立检索以下三个电子数据库：美国国立医学图书馆[医学文献数据库（PubMed）和临床试验.gov]、EMBASE（OVID）以及Cochrane对照试验中心注册库（CENTRAL）。在检索电子数据库之后，还手动检索了牙周病学和种植学领域的选定期刊。从系统综述中识别出的43项研究确定了以下分类：（1）研究——5项研究，（2）动物研究——28项研究，（3）临床研究——7项研究，（4）综述——3项研究。总结了选定的动物研究和所有人体研究的结果。这些结果表明，新型异体CO3Ap颗粒具有刺激新骨形成的潜在能力，同时CO3Ap颗粒会随着时间推移而逐渐吸收。一项研究表明，用新骨形成替代CO3Ap颗粒与自体骨移植相当，另一项研究显示其效果优于牛源异种移植物。
