Yamada K, Inoue T, Tanaka M, Furukawa T
Pharmacol Biochem Behav. 1985 Apr;22(4):645-8. doi: 10.1016/0091-3057(85)90289-8.
Effects of aniracetam (1-anysoyl-2-pyrrolodone) and piracetam (1-acetamido-2-pyrrolidone) on passive avoidance behavior were studied in 2 and 18 months old rats using a step-down passive avoidance task. Repeated administration of aniracetam (30 and 50 mg/kg, IP X 5 days) or piracetam (100 mg/kg, IP X 5 days) significantly prolonged step-down latencies for a passive avoidance task in 2 months old rats. Administration of aniracetam (50 mg/kg, IP) or piracetam (100 mg/kg, IP), however, did not affect locomotor activity. This prolongation of latencies was also seen with oral administration of aniracetam (50 mg/kg X 5 days). Similar prolongation of latencies also occurred in 18 months old rat treated with aniracetam (50 mg/kg, IP X 5 days). The results imply that aniracetam may improve learning and/or memory in 2 and 18 months old rats.
使用一步法被动回避任务，研究了茴拉西坦（1-茴酰基-2-吡咯烷酮）和吡拉西坦（1-乙酰氨基-2-吡咯烷酮）对2月龄和18月龄大鼠被动回避行为的影响。重复给予茴拉西坦（30和50mg/kg，腹腔注射×5天）或吡拉西坦（100mg/kg，腹腔注射×5天）可显著延长2月龄大鼠被动回避任务的一步下潜伏期。然而，给予茴拉西坦（50mg/kg，腹腔注射）或吡拉西坦（100mg/kg，腹腔注射）对运动活动没有影响。口服茴拉西坦（50mg/kg×5天）也可观察到潜伏期的延长。用茴拉西坦（50mg/kg，腹腔注射×5天）处理的18月龄大鼠也出现了类似的潜伏期延长。结果表明，茴拉西坦可能改善2月龄和18月龄大鼠的学习和/或记忆。
