Ye Yongli, Xu Yida, Ji Jian, Zhang Yinzhi, Feng Yongwei, Sun Xiulan
School of Food Science and Technology, International Joint Laboratory on Food Safety, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Wuxi, Jiangsu, 214122, PR China; Institute of Future Food Technology, JITRI, Yixing, Jiangsu, 214200, PR China.
School of Food Science and Technology, International Joint Laboratory on Food Safety, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Wuxi, Jiangsu, 214122, PR China; College of Biological and Food Engineering, Anhui Polytechnic University, Wuhu, Anhui, 241000, PR China.
Food Chem Toxicol. 2025 Mar;197:115314. doi: 10.1016/j.fct.2025.115314. Epub 2025 Feb 7.
Citrinin (Cit) is a metabolite of Monascus Aspergillus that is known to be nephrotoxic and affects the safety of Monascus products. Here, we investigated the effects of an intervention with bioactive Polygonatum sibiricum polysaccharides (PSPS) on Cit-induced toxic damage in populations with dietary patterns characterized by alcohol consumption. Our results showed that the PSPS intervention significantly increased the levels of intestinal Cit and its metabolite M1. Additionally, the PSPS intervention mitigated intestinal damage, as well as liver and kidney stress, and flora disruption induced by combined exposure to Cit and alcohol. It also promoted the recovery of Lactobacillus abundance. However, there was no significant improvement in hippocampal damage. Metabolomics analysis indicated that the PSPS significantly influenced the metabolic pathways involved in energy metabolism in liver and kidney, such as aspartic acid and tyrosine metabolism. Correlation analysis revealed a significant relationship between the reduction of Cit metabolites and the differential metabolites in the liver and kidney. Our results demonstrated that the PSPS intervention showed promise in improving intestinal flora imbalances, enhancing the barrier function against Cit, alleviating intestinal, liver, and kidney damage, and addressing the metabolic disorders along the gut-liver-kidney axis resulting from the co-exposure to Cit and alcohol.
桔霉素（Cit）是红曲霉菌和曲霉菌的一种代谢产物，已知具有肾毒性并影响红曲产品的安全性。在此，我们研究了生物活性黄精多糖（PSPS）干预对以饮酒为特征的饮食模式人群中Cit诱导的毒性损伤的影响。我们的结果表明，PSPS干预显著提高了肠道中Cit及其代谢产物M1的水平。此外，PSPS干预减轻了肠道损伤以及肝脏和肾脏的应激反应，以及由Cit和酒精联合暴露引起的菌群紊乱。它还促进了乳酸杆菌丰度的恢复。然而，海马体损伤没有明显改善。代谢组学分析表明，PSPS显著影响肝脏和肾脏中参与能量代谢的代谢途径，如天冬氨酸和酪氨酸代谢。相关性分析揭示了Cit代谢产物的减少与肝脏和肾脏中差异代谢产物之间存在显著关系。我们的结果表明，PSPS干预在改善肠道菌群失衡、增强对Cit的屏障功能、减轻肠道、肝脏和肾脏损伤以及解决因同时暴露于Cit和酒精而导致的沿肠-肝-肾轴的代谢紊乱方面显示出前景。
