Mukherjee Koushik, Amaranath Bj Janardhana, Das Neelam, Dhanai Anishka, Pallavi Kumari, Katiyar Priya
Department of Periodontology, Rama Dental College Hospital and Research Centre, Rama University, Mandhana, Kanpur, Uttar Pradesh, India.
J Pharm Bioallied Sci. 2024 Dec;16(Suppl 4):S3332-S3334. doi: 10.4103/jpbs.jpbs_738_24. Epub 2024 Dec 12.
The aim of this article is to evaluate and compare the efficacy of subgingival application of ozonated olive oil, plain olive oil, and chlorhexidine gel as an adjunct to scaling and root planing (SRP) in chronic periodontitis.
One hundred and twenty patients with chronic periodontitis were included in this study and assigned into three groups. In Group I, Group II, and Group III, SRP was done followed by subgingival application of ozonated olive oil, plain olive oil, and chlorhexidine gel in Group I, II, and III, respectively, at baseline 7, 14, and 21 days. Recordings of clinical parameters (gingival index [GI], probing pocket depth [PPD], clinical attachment level [CAL]) were done at baseline and one month.
The mean GI, PPD, and CAL scores at baseline for Group I was 2.78 ± 0.42, 2.78 ± 0.42, and 2.66 ± 0.38; for Group II was 2.64 ± 0.39, 6.40 ± 0.50, and 6.40 ± 0.50; and for Group III was 6.00 ± 0.00, 6.40 ± 0.50, and 6.40 ± 0.50, and the scores after one month for Group I was 1.10 ± 0.38, 0.21 ± 0.07, and 0.07 ± 0.05; for Group II was 0.05 ± 0.05, 5.40 ± 0.50, and 5.75 ± 0.44; and for Group III was 5.00 ± 0.00, 5.75 ± 0.44, and 5.28 ± 0.45, with the level of significance being ( < 0.001).
The ozonated olive oil and chlorhexidine gel have shown significant improvement in periodontal health compared to plain olive oil. Ozonated olive oil can be used as local drug delivery (LDD), an adjunct to SRP in chronic periodontitis which is safe and well accepted by patients without any noticeable side effects.
本文旨在评估和比较龈下应用臭氧化橄榄油、普通橄榄油和氯己定凝胶作为慢性牙周炎龈上洁治和根面平整(SRP)辅助治疗的疗效。
120例慢性牙周炎患者纳入本研究并分为三组。第一组、第二组和第三组均进行SRP,然后分别于基线、第7天、第14天和第21天在第一组、第二组和第三组龈下应用臭氧化橄榄油、普通橄榄油和氯己定凝胶。在基线和1个月时记录临床参数(牙龈指数[GI]、探诊袋深度[PPD]、临床附着水平[CAL])。
第一组基线时的平均GI、PPD和CAL评分分别为2.78±0.42、2.78±0.42和2.66±0.38;第二组为2.64±0.39、6.40±0.50和6.40±0.50;第三组为6.00±0.00、6.40±0.50和6.40±0.50。1个月后第一组的评分分别为1.10±0.38、0.21±0.07和0.07±0.05;第二组为0.05±0.05、5.40±0.50和5.75±0.44;第三组为5.00±0.00、5.75±0.44和5.28±0.45,显著性水平为(<0.001)。
与普通橄榄油相比,臭氧化橄榄油和氯己定凝胶在牙周健康方面有显著改善。臭氧化橄榄油可作为局部药物递送(LDD),作为慢性牙周炎SRP的辅助治疗,安全且患者易于接受,无明显副作用。